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SUMMARY:Re-engineering Developmental Processes for Cartilage and Bone Rege
 neration
DTSTART:20190325T121500
DTSTAMP:20260407T051251Z
UID:c88e828d7157e9b6d888e4cdc2f05b4c7ffcd60b748ad16eef893a76
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Ivan Martin\, University Hospital Basel (CH)\nWEEKLY BIO
 ENGINEERING COLLOQUIA SERIES\n(sandwiches served)\n\nAbstract: \nBiologica
 l processes leading to tissue formation during embryonic development are c
 haracterized by a large stability and reproducibility of events\, typicall
 y referred to as ‘robustness’. Would regenerative medicine approaches 
 be more repeatable and effective if they targeted the recapitulation of mo
 lecular pathways typical of tissue development? Within the exemplifying co
 ntext of cartilage and bone repair\, this lecture will introduce and discu
 ss the challenges and opportunities of regenerative concepts based on mimi
 cking developmental processes. Rather than engineering a tissue\, the stra
 tegy would target the use of cells (e.g.\, mesenchymal stromal cells) to e
 ngineer temporally staged processes\, recapitulating events of development
  (e.g.\, endochondral ossification for bone or joint cavitation for articu
 lar cartilage). The product would be a construct containing the necessary 
 and sufficient cues to autonomously remodel into the target repair tissue 
 upon grafting.\nIn this perspective\, however\, cells in adults may strong
 ly differ from multipotent embryonic cells\, and typically reside in an en
 vironment\, which is tightly regulated by post-natal mechanical conditioni
 ng or immune/inflammatory processes. Thus\, shouldn’t tissue regeneratio
 n strategies be inspired by development but adapted to be effective in a c
 ontext\, which is different from the embryo? This would require to re-desi
 gn the developmental machinery for regenerative purposes by establishing a
 rtificial events or conditions. Will the resulting approach of ‘developm
 ental re-engineering’ offer a chance for enhanced regeneration to those 
 tissues with limited capacity to recover from injuries or within pathologi
 cal settings reducing the potential for endogenous repair?\n\nZoom link fo
 r attending remotely: https://epfl.zoom.us/j/133566960\n \n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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