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SUMMARY:Functional Ultrasound (fUS) Imaging:  a new neuroimaging modality 
 for neuroscience
DTSTART:20190115T121500
DTEND:20190115T131500
DTSTAMP:20260930T215044Z
UID:deeeaaabd44701c6a09fd29d0f602fc36d8b56eafd0795920e452fdf
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof Mickael Tanter\, Institut Langevin\, ESPCI\, Paris\, Fran
 ce.\nIn the last twenty years\, the progressive introduction of plane or d
 iverging ultrasonic wave transmissions rather than line by line scanning f
 ocused beams broke the resolution limits of ultrasound imaging. By using s
 uch large field of view transmissions\, the frame rate reaches the theoret
 ical limit of physics dictated by the ultrasound speed and an ultrasonic m
 ap can be provided typically in tens of micro-seconds (several thousands o
 f frames per second). Interestingly\, this leap in frame rate is not only 
 a technological breakthrough but it permits the advent of completely new u
 ltrasound imaging modes\, including shear wave elastography\, electromecha
 nical wave imaging\, ultrafast Doppler\, ultrafast contrast imaging\, and 
 even functional ultrasound imaging (fUS imaging) of brain activity  intro
 ducing Ultrasound as an emerging full-fledged neuroimaging modality. At ul
 trafast frame rates\, it becomes possible to track in real time the transi
 ent vibrations – known as shear waves – propagating through organs. Su
 ch "human body seismology" provides quantitative maps of local tissue stif
 fness whose added value for diagnosis has been recently demonstrated in ma
 ny fields of radiology (breast\, prostate and liver cancer\, cardiovascula
 r imaging\, ...). For blood flow imaging\, ultrafast Doppler permits high-
 precision characterization of complex vascular and cardiac flows. It also 
 gives ultrasound the ability to detect very subtle blood flow in very smal
 l vessels. In the brain\, such ultrasensitive Doppler paves the way for fU
 ltrasound or fUS (functional ultrasound) imaging of brain activity with un
 precedented spatial and temporal resolution compared to fMRI. It provides 
 the first modality for imaging of the whole brain activity working on awak
 e and freely moving animals with unprecedented resolutions and was also tr
 anslated recently to clinics.\n\nFinally\, we recently demonstrated that i
 t can be combined with 3 µm diameter microbubbles injections in order to 
 provide a first in vivo and non-invasive imaging modality at microscopic s
 cales deep into organs combined with contrast agents by localizing the pos
 ition of millions of microbubbles at ultrafast frame rates. This ultrasoun
 d localization microscopy technique solves for the first time the problem 
 of in vivo imaging at microscopic scale the whole brain vasculature. Beyon
 d fundamental neuroscience or stroke diagnosis\, it will certainly provide
  new insights in the understanding of tumor angiogenesis\, for example com
 bined with PET/CT imaging.\n\nBio\nMickael Tanter is a research professor 
 of the French National Institute for Health and Medical Research (Inserm) 
 and distinguished professor of ESPCI Paris. He is heading the laboratory 
 “Physics for Medicine” and deputy director of Langevin Institute (CNRS
 ) at ESPCI\, Paris\, France. He is also the director of the first INSERM T
 echnology Research Accelerator created in 2016 and dedicated to Biomedical
  Ultrasound. Mickael Tanter is a world-renowned expert in biomedical ultra
 sound and wave physics. He authored more than 300 peer-reviewed papers and
  book chapters and is the recipient of 45 international patents. In the la
 st 20 years\, he co-invented several major innovations in Biomedical Ultra
 sound: Transient Elastography\, Ultrafast Ultrasound and Shear Wave Elasto
 graphy\, functional Ultrasound (fUS) imaging of brain activity and Superre
 solution Ultrasound based on Ultrasound Localization Microscopy. He receiv
 ed many national and international distinctions (among them the Honored Le
 cture of the Radiology Society of North America in 2012\, the Grand Prize 
 of Medicine and Medical Research of Paris city in 2011\, the Grand Prize o
 f Fondation de la Recherche Médicale in 2016 and the Carl Hellmuth Hertz 
 Prize of IEEE Ultrasonics\, Ferroelectrics and Frequency Control society i
 n 2017\, and recently the highest distinction of the European Society in M
 olecular Imaging ESMI). M. Tanter is also the co-founder of several MedTec
 h companies in Biomedical Ultrasound (Supersonic Imagine\, CardiaWave\, Ic
 oneus).
LOCATION:Campus Biotech\, H8 Auditorium D https://plan.epfl.ch/?room=H8114
 4.167
STATUS:CONFIRMED
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