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SUMMARY:Biophysical Aspects of T Cell Activation
DTSTART:20190520T121500
DTSTAMP:20260929T064726Z
UID:e30f60ed6681833361454399e16bd6ff585526b287d917ffdaa0d716
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Claire Hivroz\, Institut Curie\, Paris (F)\nWEEKLY BIOEN
 GINEERING COLLOQUIA SERIES\n(sandwiches served)\n\nAbstract: \nWhen a migr
 ating T cell contacts an antigen presenting cell (APC)\, and when it forms
  a radially symmetric mature immune synapse (IS)\, multiple forces are exe
 rted on the molecules involved in the contacts between the two cells. Henc
 e\, molecular contacts between TCR and pMHC\, integrins and their ligands\
 , and costimulatory molecules and their ligands are submitted to constant 
 strain. These forces can change the kinetics of association/dissociation b
 etween the receptors and their ligands and induce conformational changes t
 hat might induce signaling cascades. Studies from others and us have shown
  that the generation of molecular forces at the IS is induced by TCR trigg
 ering and that T cells respond differently depending on the mechanical pro
 perties of the stimulatory surfaces they encounter. This corresponds to an
  adaptation of the forces generated at the IS to the substrate stiffness. 
 These evidences suggest that mechanical force is integrally involved in T 
 cell activation. We will discuss 1) how TCR triggering induces forces that
  can adapt to the rigidity of the substrates. 2) the viscoelastic properti
 es of myeloid APCs and their regulation by inflammation. 3) how the viscoe
 lastic properties of the environment can modify the functional program of 
 T lymphocytes.\n\nPublications on the subject:\n\n	Sawicka A\, Babataheri 
 A\, Dogniaux S\, Barakat AI\, Gonzalez-Rodriguez D\, Hivroz C*\, Husson J*
 . 2017. Micropipette force probe to quantify single-cell force generation:
  application to T-cell activation. Mol Biol Cell 28: 3229-39. * Co-corresp
 onding authors.\n	Saitakis M\, Dogniaux S\, Goudot C\, Bufi N\, Asnacios S
 \, Maurin M\, Randriamampita C\, Asnacios A*\, Hivroz C*. 2017. Different 
 TCR-induced T lymphocyte responses are potentiated by stiffness with varia
 ble sensitivity. Elife 6. * Co-corresponding authors.\n	Hivroz C\, Saitaki
 s M. 2016. Biophysical Aspects of T Lymphocyte Activation at the Immune Sy
 napse. Front Immunol 7: 46\n	Bufi N\, Saitakis M\, Dogniaux S\, Buschinger
  O\, Bohineust A\, Richert A\, Maurin M\, Hivroz C*\, Asnacios A*. 2015. H
 uman Primary Immune Cells Exhibit Distinct Mechanical Properties that Are 
 Modified by Inflammation. Biophys J 108: 2181-90. * Co-corresponding autho
 rs.\n	Husson J\, Chemin K\, Bohineust A\, Hivroz C*\, Henry N*. 2011. Forc
 e generation upon T cell receptor engagement. PLoS ONE 6: e19680. * Co-cor
 responding authors.\n\n\nBio:\nSince 2002: Director of Research at the INS
 ERM (DR2)\nSince 1998: Team leader (INSERM U932\, Immunité et Cancer) at 
 the Curie Institute\, Paris\, F\n1991-1998: Postdoctoral position\, then t
 eam leader in INSERM U429\, Hôpital Necker\, Paris\, F\n1989-1991: Postdo
 ctoral position at Imperial Cancer Research Fund.\, London\, UK\n1985-1989
 : PhD student\, Hôpital Saint-Louis\, Paris\, F\; PhD from University Par
 is 7\n1985: D.E.A. from University Paris 7\, Hôpital Saint Louis\, Paris\
 , F\n\n\nZoom link for attending remotely:   https://epfl.zoom.us/j/2495
 02771\n 
LOCATION:MED 2 1522 https://plan.epfl.ch/?room=MED21522
STATUS:CONFIRMED
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