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SUMMARY:How Fast Are Functional Motions of Protein Machines? A Single-Mole
 cule Perspective
DTSTART:20190513T121500
DTSTAMP:20260430T215502Z
UID:148305dee438abb6a469d9ceede5f6b5e06b4d4817fe27e32eb404e3
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Gilad Haran\, Weizmann Institute of Science\, Rehovot (I
 L)\nWEEKLY BIOENGINEERING COLLOQUIA SERIES\n(sandwiches served)\n\nAbstrac
 t: \nProtein machines carry out multiple tasks in the cell\, but their mod
 es of operation are still quite obscure. Single-molecule fluorescence spec
 troscopy is a powerful tool for exposing function-related motions of such 
 nanomachines. We recently developed novel methodology that allows us to tr
 ack protein dynamics even on the microsecond time scale. In the lecture\, 
 I will show how this analysis helped us understanding the dynamics of two 
 different machines. Surprisingly\, internal motions are found to be faster
  than chemical steps by 2-3 orders of magnitude\, which we will try to rat
 ionalize in the lecture.\n\nBio:\nGilad Haran is a Professor in the Depart
 ment of Chemical and Biological Physics at the Weizmann Institute of Scien
 ce. He did his Ph.D. in Biophysics at the Weizmann Institute and his post-
 doc in Chemical Physics in the U. of Pennsylvania. He holds the Hilda Pome
 raniec Memorial Professorial Chair. He served as the Dean of the Faculty o
 f Chemistry at Weizmann from 2012 to 2018. His research revolves around st
 udies of single molecules and particles. He is interested in particular in
  studies of protein folding and dynamics using single-molecule FRET spectr
 oscopy. His lab developed original methods for performing and analyzing si
 ngle-molecule experiments. He is also studying individual plasmonic device
 s strongly coupled to molecules and quantum dots. Gilad Haran is a recipie
 nt of a 2017 European Research Council Advanced Grant. He was awarded the 
 Weizmann Prize of the Tel Aviv Municipality in 2017 and was elected Biophy
 sical Society Fellow in 2019.\n\n\nZoom link for attending remotely:  htt
 ps://epfl.zoom.us/j/724143873
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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