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SUMMARY:An omics journey through the intriguing world of adipose biology
DTSTART:20190215T123000
DTEND:20190215T133000
DTSTAMP:20260427T224727Z
UID:e138596af87cd40e0e814d22f3492180ba16ddecb8a0f0d7c29a4027
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr Bart Deplancke\, FSV / IBI / UPDEPLA\n\nAbstract :\nGiven 
 the world-wide increase in obesity\, studying the onset of this debilitati
 ng syndrome and specifically the dynamic nature of fat tissue is of great 
 interest. In this presentation\, I intend to summarize my lab’s efforts 
 in addressing multiple\, outstanding questions related to adipose biology.
  First\, I will show how we are using integrative genomic approaches to be
 tter understand the transcriptional networks that drive terminal fat cell 
 differentiation\, highlighting several studies that allowed us to uncover 
 novel\, central regulators of this process. Second\, I will demonstrate th
 e power of single cell transcriptomics in allowing us to acquire a high-re
 solution snapshot of adipose stromal cell heterogeneity\, revealing severa
 l distinct subpopulations. Surprisingly\, we found that one subpopulation 
 is not only refractory to adipogenesis\, but also exhibits a remarkable ca
 pacity to inhibit in vitro and in vivo mammalian adipocyte formation. The 
 discovery of these adipogenesis-regulatory cells (“Aregs”) is signific
 ant as it may fundamentally change our thinking of how the composition and
  plasticity of fat depots is regulated. Finally\, I will discuss our lates
 t efforts in better understanding the genetic and molecular determinants u
 nderlying adipose-related human traits. I will thereby introduce the conce
 pt of “variable chromatin modules” that we have recently coined and sh
 ow how this concept can assist us in uncovering the flow of molecular info
 rmation from regulatory variant to adipose-related phenotype.\n\nBio :\nBa
 rt Deplancke graduated as a Biochemical Engineer at Ghent University (Belg
 ium\, 1998) after which he pursued doctoral studies in Immunobiology at th
 e University of Illinois (USA). Thereafter\, he engaged in postdoctoral\, 
 regulatory genomics work in the laboratories of Marc Vidal and Marian Walh
 out (Harvard and UMass Medical Schools respectively) during which he devel
 oped a now patented\, high-throughput protein-DNA interaction screening ap
 proach. To establish his own lab at the EPFL at the end of 2007 where he i
 s now a tenured Associate Professor and Vice-Dean of Innovation\, he decid
 ed to continue developing new experimental and computational approaches to
  answer questions related to the biology of the genome. The Deplancke Lab 
 has by now built a sizeable toolkit\, involving microfluidics\, high-throu
 ghput sequencing\, and single cell genomics\, to address questions pertain
 ing to the origin\, diversity and function of stromal cells in adipose tis
 sue as well as to how genomic variation affects molecular and organismal d
 iversity with a specific focus on metabolic phenotypes. In 2013\, he also 
 became a Swiss Institute of Bioinformatics Group Leader and in 2017\, he w
 as elected to the National Research Council of the Swiss National Science 
 Foundation.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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