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SUMMARY:BMI SEMINAR // Gioele La Manno - RNA velocity of single cells to u
 nveil the developmental dynamics of the nervous system
DTSTART:20190130T121500
DTEND:20190130T131500
DTSTAMP:20260916T013447Z
UID:299d2e3793e795d184b23c934ce9031c8d209f4c582e0e8a837e3ceb
CATEGORIES:Conferences - Seminars
DESCRIPTION:Gioele La Manno\, Neurodevelopmental systems biology lab\, Bra
 in Mind Institute\, EPFL\nAn ambitious goal of single-cell analyses is to 
 describe dynamical biological processes and shed light on gene regulation.
  However\, the destructive nature of transcriptomics measurements constitu
 tes an immediate challenge to this purpose.  To overcome this fundamental
  limit\, we present a novel method capable of estimating “RNA velocity
 ”: the time derivative of gene expression. We apply the analysis framewo
 rk to multiple datasets and techniques\, and to study developmental lineag
 es in the developing nervous system. We use RNA velocity to gain insight i
 nto a branching single-cell atlas of the developing brain\, an analysis ta
 sk of significant complexity. In summary\, we discovered that single cell 
 datasets contain\, previously unsuspected\, temporal information and we de
 veloped an analytical framework to harness it to study nervous system deve
 lopment.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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