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SUMMARY:Towards increased selectivity of cancer treatment by Photodynamic 
 therapy
DTSTART:20120531T140000
DTSTAMP:20260427T203631Z
UID:d0d17de829b58e962f840cbe74d0d732529fc8b8abd1cbae6861a0a3
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Pavol Miskovsky of Safarik University\, Slovakia\nDevelo
 pment of selective nano-delivery system and detection of therapeutically a
 ctive form of drugs in cell\n\nThe efficacy of photosensitiers (pts) in in
 ducing either apoptosis or necrosis after photodynamic action critically d
 epends upon different parameters\, including\, in particular: i) selective
  pts accumulation in tumor cells and\, ii) dynamics of sub-cellular distri
 bution of therapeutically active form of drug.\n\nLow-density lipoproteins
  (LDL) play a key role in the delivery of hydrophobic pts to tumor cells i
 n PDT\, including hypericin (Hyp). Construction and characterization of ne
 w LDL-based selective nano-delivery system is discussed in the presentatio
 n.\n\nDynamics of organelle specific sub-cellular redistribution of Hyp pl
 ays an important role in its photodynamic activity. In this presentation\,
  we report the development and characterization of micrometer-sized dielec
 tric beads with nano-metal structures attached to their surface. The metal
 ized beads are sufficiently transparent enabling optical trapping while th
 e presence of metal nano-islands provided the SERS. This highly efficient 
 probe can be placed and scanned with nano-metric accuracy in living cells.
  Application of such optical nano-sensors is demonstrated on: i) detection
  of low quantities of photoactive drug emodine\, (ii) study the kinetics o
 f drug diffusion through the cellular membrane towards specific cell organ
 elles.
LOCATION:CH G1 495 https://plan.epfl.ch/?room==CH%20G1%20495
STATUS:CONFIRMED
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