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SUMMARY:Nuclear Receptors and Metabolism: From Feast to Famine
DTSTART:20120622T160000
DTEND:20120622T170000
DTSTAMP:20260916T043957Z
UID:45eddbed4e44d9ac30d0d6071dbd5cfc0f82f37ac07dae8a4ca65a3f
CATEGORIES:Conferences - Seminars
DESCRIPTION:Ronald M. Evans\, Professor\nDirector - Gene Expression Labora
 tory Salk Institute for Biological Studies\nMarch of Dimes Chair in Molecu
 lar and Developmental Biology \n\nHHMI Investigator\n\nHoward Hughes Medi
 cal Institute - The Salk Institute for Biological Studies\, La Jolla\, CA
   - USA\n\nweb:\nhttp://www.salk.edu/faculty/evans.html\nhttp://www.hhmi.
 org/research/investigators/evans_bio.html\n-----\n\nSurvival requires the 
 ability to adapt to cycles of feast and famine yet the underlying  mechan
 isms to maintain metabolic balance during extremes of nutrient challenge r
 emain poorly understood.  As part of a screen to identify genes that resp
 ond to feast and famine cues\, we discovered that FGF1 is induced in white
  adipose tissue (WAT) in response to high-fat-diet (HFD) and repressed dur
 ing a fast\, pointing to an unexpected metabolic function. Thus\, FGF1 par
 ticipates in both fed-state and fasted-state responses.  In WAT\, FGF1 is
  induced by HFD through a PPAR-gamma dependent mechanism.  On HFD\, FGF1 
 deficient mice develop an aggressive diabetic phenotype\, with adipose tis
 sue becoming inflamed and unable to adapt to nutrient excess. As loss of F
 GF1 results in a diabetic phenotype\, synthetic FGF1 could be as a new cla
 ss of insulin sensitizer.\n\nMammalian metabolism is highly circadian and 
 major hormonal circuits involving nuclear hormone receptors display interl
 inked diurnal cycling. However\, mechanisms that logically explain the coo
 rdination of nuclear hormone receptors and the clock are poorly understood
 . Recently we have shown that two circadian co-regulators\, Cryptochrome 1
 /2 (Cry 1 and 2)\, and Rev-erb a&b act in the liver to control both lipoge
 nic and gluconeogenic programs.  These observations expand our understand
 ing of how metabolism is coordinated with geophysical time.  
LOCATION:SV 1717A
STATUS:CONFIRMED
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