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SUMMARY:“Prison Break” Toxoplasma egress from infected cells is a tigh
 tly programmed event controlled by a lipid mediator
DTSTART:20190115T121500
DTSTAMP:20260528T175114Z
UID:0ebb82fbb6a085e567389e2e19a7b9e0a8b42c75c76d14c0a5e2f120
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dominique Soldati-Favre\, Department of Microbiology and Molec
 ular Medicine\, UNIGE\nThe phylum Apicomplexa groups obligate intracellula
 r parasites responsible for severe veterinary and human diseases. The most
  ubiquitous member of the phylum\, Toxoplasma gondii establishes a life-lo
 ng chronic infection in human and animals. Gliding motility\, a substrate-
 dependent form of locomotion\, powered by an actomyosin system\, assists i
 nvasion and egress from the infected cells\, two key steps in the lytic cy
 cle of the Apicomplexa. Egress from infected cells is a temporally orchest
 rated process underpinned by the release of the apical secretory organelle
 s termed micronemes. At any point during intracellular replication\, T. go
 ndii tachyzoites are able to egress in response to deleterious environment
 al changes by activation of the cGMP-dependent protein kinase. This leads 
 to a raise in intracellular calcium and production of intracellular phosph
 atidic acid\, two key mediators of microneme adhesins exocytosis and their
  connection to the actomyosin system. We recently uncovered that in absenc
 e of extrinsic (alarming) signals\, a diacylglycerol kinase secreted into 
 the parasitophorous vacuole\, produces phosphatidic acid\, which dictates 
 programmed egress after five to six cycles of parasite multiplication. Pho
 sphatidic acid acts as an intrinsic signal that elicits natural egress ups
 tream of an atypical guanylate cyclase\, which is uniquely conserved in al
 veolates and ciliates and composed of a P4-ATPase and two guanylate cyclas
 e catalytic domains. This study proposes a newly mechanism by which guanyl
 ate cyclase activated to govern natural egress.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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