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SUMMARY:Engineering 3D Culture Models of Physiology and Disease: How Simpl
 e is Complex Enough?
DTSTART:20190121T121500
DTSTAMP:20260427T220008Z
UID:495283edbadf207bf65adf0af5193c6abbaba12931654209527dcee6
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Christopher Chen\, Boston University and Harvard Wyss In
 stitute\, Boston\, MA (USA)\nDISTINGUISHED LECTURE IN BIOENGINEERING\n(san
 dwiches served)\n\nAbstract: \nMulticellular ecosystems such as biofilms\,
  tissues\, and whole organisms operate as highly integrated systems that l
 ink physical structure and biological function. In mammalian tissues\, str
 ucture determines the effectiveness by which muscles generate force\, lung
 s oxygenate blood\, or glandular organs produce bile\, milk\, or saliva. E
 ven at the level of single cells\, tissue structure constrains how cells i
 nteract with surrounding extracellular matrix\, neighboring cells\, and ph
 ysical forces\, and these “microenvironmental” cues in turn regulate c
 ell function at a fundamental level. Here\, I will describe our efforts to
  design and generate functional tissue architectures most relevant to the 
 cardiovascular system\, using a variety of fabrication and cell-driven ass
 embly approaches. We will present ongoing efforts to build in vitro organo
 typic models that mimic native tissue functions\, studies to examine integ
 ration of engineered structures in vivo\, and discuss opportunities and ch
 allenges for how to connect these insights to the ultimate translational o
 bjectives set by regenerative medicine.\n\nBio:\nDr. Chen is Professor of 
 Biomedical Engineering and director of the Tissue Microfabrication Laborat
 ory at Boston University. He has been an instrumental figure in the develo
 pment of engineered cellular microenvironments in order to engineer cell f
 unction. The goal of Dr. Chen’s research is to identify the underlying m
 echanisms by which cells interact with materials and each other to build t
 issues\, and to apply this knowledge in the biology of stem cells\, tissue
  vascularization\, connective tissues\, and cancer. He has received numero
 us honors\, including the Presidential Early Career Award for Scientists a
 nd Engineers\, the Angiogenesis Foundation Fellowship\, the Office of Nava
 l Research Young Investigator Award\, the Mary Hulman George Award for Bio
 medical Research\, and the Herbert W. Dickerman Award For Outstanding Cont
 ribution to Science. He serves a Fellow of the American Institute for Medi
 cal and Biological Engineering\, and as a member of the Faculty of 1000 Bi
 ology\, the Board of Trustees for the Society for BioMEMS and Biomedical N
 anotechnology\, and Defense Sciences Study Group. He is on the Editorial B
 oard for Science Translational Medicine\, Annuals Reviews of Cell and Deve
 lopmental Biology\, and Developmental Cell\, and an Editor for Journal of 
 Cell Science\, BioInterphases\, Technology\, and Molecular and Cellular Bi
 oengineering.\nHe received his A.B. in Biochemistry from Harvard\, M.S. in
  Mechanical Engineering from MIT\, and Ph.D. in Medical Engineering and Me
 dical Physics from the Harvard-MIT. Health Sciences and Technology Program
 . He earned his M.D. from the Harvard Medical School. Dr. Chen was previou
 sly was Assistant Professor in Biomedical Engineering and in Oncology at J
 ohns Hopkins University\, the Skirkanich Professor of Innovation and found
 ing director of the Center for Engineering Cells and Regeneration at the U
 niversity of Pennsylvania.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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