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SUMMARY:Toward Point-of-Care Assessment of Hemostasis Using Miniaturized D
 ielectric Coagulometry
DTSTART:20190304T101500
DTEND:20190304T113000
DTSTAMP:20260919T231221Z
UID:d6101dd8f1f3afd02b091e5c14478eb102b0a28e0b379af36079eab0
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Dr. Pedram Mohseni\nCase Western Reserve University\nIns
 titute of Microengineering - Distinguished Lecture\n\nCampus Lausanne SV 1
 717 (live)\nCampus Microcity MC B0 302 (video)\nZoom Live Stream: https://
 epfl.zoom.us/j/204283294\n\nAbstract: Point-of-care (POC) diagnostic devic
 es hold great promise to significantly impact healthcare delivery and addr
 ess health disparities by shifting the focus away from the utilization of 
 high-cost specialized care for the treatment of late-stage diseases toward
  predictive\, preventative\, and personalized health for more effective di
 sease monitoring and management. In the developed world\, POC technologies
  are expected to offer effective and feasible means of reducing healthcare
  costs and improving patient care\, whereas in the developing world POC te
 chnologies are urgently needed to address pressing healthcare needs with a
 ffordable and accessible solutions.\nIn this lecture\, I will first provid
 e a brief overview of the field of POC technologies for health diagnostics
 . To showcase an example\, I will next present our work on ClotChip\, a mi
 crofluidic sensor that utilizes dielectric spectroscopy for POC assessment
  of blood coagulation disorders with <10 uL of whole blood. Specifically\,
  I will analyze a simple circuit model that accurately captures the freque
 ncy-dependent dielectric behavior of human whole blood placed within a mic
 rofluidic channel. I will then discuss how temporal variation in the diele
 ctric properties of the blood sample undergoing coagulation provides infor
 mation about molecular and cellular abnormalities in the hemostatic proces
 s.\nFinally\, to establish the utility of ClotChip as a platform technolog
 y for POC assessment of hemostasis\, I will share our results from pilot c
 linical studies with ClotChip on monitoring anticoagulation therapy with a
  new class of FDA-approved blood thinners as well as coagulation factor re
 placement therapy in hemophilia care management. Results from correlative 
 studies between ClotChip and several existing blood coagulation assays are
  also provided.\n\nBio: Pedram Mohseni received the B.S. degree from the S
 harif University of Technology\, Tehran\, Iran\, in 1996\, and the M.S. an
 d Ph.D. degrees from the University of Michigan\, Ann Arbor\, MI\, USA\, a
 ll in electrical engineering\, in 1999 and 2005\, respectively. Currently\
 , he is a Professor and Associate Chair in the Electrical Engineering and 
 Computer Science Department at Case Western Reserve University\, Cleveland
 \, OH\, USA\, with a secondary appointment in the Biomedical Engineering D
 epartment. His research interests include analog/mixed-signal/RF integrate
 d circuits and microsystems for neural engineering\, wireless sensing/actu
 ating systems for brain-machine interfaces\, interface circuits for micro/
 nano-scale sensors/actuators\, and point-of-care diagnostic platforms for 
 personalized health. Dr. Mohseni has been an Associate Editor for several 
 IEEE journals since 2008\, as well as a member of the Technical Program Co
 mmittee (TPC) of the IEEE RFIC Symposium (2012-2015)\, CICC (2012-present)
 \, and ISSCC (2017-present). The author of two book chapters\, six issued 
 and pending patents\, and over 105 refereed technical and scientific artic
 les\, he has received several awards including the National Science Founda
 tion CAREER Award\, Case School of Engineering Research Award\, first-plac
 e prize of the Medical Device Entrepreneur’s Forum at the 58th annual co
 nference of the ASAIO\, and EECS Mihajlo “Mike” Mesarovic Award for Ex
 traordinary Impact. He has been a member of the IEEE Solid-State Circuits\
 , Circuits and Systems\, and Engineering in Medicine and Biology Societies
 \, as well as the administrative committee of the IEEE Sensors Council (20
 14-2017). Dr. Mohseni was the TPC co-Chair of the IEEE BioCAS conference i
 n 2017 and General co-Chair of the conference in 2018.\n\nNote: The Semina
 r Series is eligible for ECTS credits in the EDMI doctoral program. 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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