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SUMMARY:Neural Circuits & Behavior Process Report // Bianca Silva - A thal
 amo-amygdalar circuit underlies remote fear memory attenuation
DTSTART:20190214T093000
DTEND:20190214T103000
DTSTAMP:20260407T095032Z
UID:91cff974ecc12f53777d91778f8d31eec10a0ddde055f49597c53b0a
CATEGORIES:Conferences - Seminars
DESCRIPTION:Bianca Silva\, Prof. Gräff's Lab\nDespite the rising prevalen
 ce of trauma-related disorders and the consequent need to better understan
 d how long-lasting traumatic memories are attenuated\, the brain areas sup
 porting this process remain largely unknown. Here\, we show – using real
 -time fiber photometry recordings\, bidirectional chemogenetic manipulatio
 ns and functional circuit mapping in vivo – that the ventromedial thalam
 us (VMT) mediates remote fear memory attenuation in the mouse. During expe
 rimental extinction of remote fear memories\, the VMT increases in activit
 y before the end of freezing bouts. Correspondingly\, inhibiting VMT activ
 ity impairs\, while activating ameliorates remote fear attenuation. VMT ou
 tputs to the basal amygdala (BA) mediate this mitigating effect\, stipulat
 ing that the VMT provides safety signals to the BA. These findings identif
 y a critical node for remote fear memory attenuation and foster our unders
 tanding of traumatic memory processing\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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