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SUMMARY:Neural Circuits & Behavior Process Report //  - Adult dentate gyru
 s neurogenesis: from integration to function
DTSTART:20190905T093000
DTEND:20190905T103000
DTSTAMP:20260509T203642Z
UID:87319d0862869b295adafceb288447e0dcecaedc3359d2463ddd3b58
CATEGORIES:Conferences - Seminars
DESCRIPTION:  Olivia Gozel Prof. Gerstner's Lab\nIn adult dentate gyrus n
 eurogenesis\, the link between maturation of newborn neurons and their fun
 ction\, such as behavioral pattern separation\, has remained puzzling. By 
 analyzing a theoretical model\, we show that the switch from excitation to
  inhibition of the GABAergic input onto maturing newborn cells is crucial 
 for their proper functional integration. When the GABAergic input is excit
 atory\, cooperativity drives the growth of synapses such that newborn cell
 s become sensitive to stimuli similar to those that activate mature cells.
  When GABAergic input switches to inhibitory\, competition pushes the conf
 iguration of synapses onto newborn cells towards representations that are 
 away from previously stored memories. This enables the maturing newborn ce
 lls to code for concepts that are novel\, yet similar to familiar ones. Ou
 r theory of newborn cell maturation can explain how adult newborn cells in
 tegrate into the preexisting network and why they promote pattern separati
 on for similar stimuli.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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