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PRODID:-//Memento EPFL//
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SUMMARY:Neural Circuits & Behavior Progress Report // Carolina Cela - A Co
 mm2/Robo2/Slit signalling pathway regulates synaptic terminal arborisation
DTSTART:20191003T093000
DTEND:20191003T103000
DTSTAMP:20260504T080627Z
UID:db37f94e7b294994849d3b9a9004230a969e438bcefb3b2e6e1bf730
CATEGORIES:Conferences - Seminars
DESCRIPTION:Carolina Cela\, Prof. McCabe's Lab\nSynaptic terminal archite
 ctural maturation is a critical component of neuronal circuit amalgamation
  involving a compendium of morphological elaborations of synaptic structu
 res. Analysis of the development of Drosophila neuromuscular junction 
 (NMJ) synaptic terminals has primarily focused on the regulation of synap
 tic terminal size with other features of maturation remaining mostly une
 xplored. To address this deficit\, we have investigated the process of s
 ynaptic terminal arborisation or branching. We find that\, in contrast to
  previous assumptions\, terminal branching does not take place throughou
 t development\, but instead occurs during a critical time window soon aft
 er embryos hatch. During this period the branching pattern of the synaptic
  terminal is defined and the majority of all terminal arbours form. To i
 dentify the genetic control of this process\, we carried out a mutant scr
 een and identified Commisureless 2 (comm2) as a novel key negative regu
 lator of synapse arborisation. Comm2 shares homology to Comm\, a well-des
 cribed regulator of Robo signalling during neuronal axon guidance. We fin
 d that at synapses Comm2 regulates the Robo family member Robo2 which is 
 required to promote terminal arborisation in response to a Slit ligand si
 gnal. Our results establish a new role for Slit/Robo signalling in matur
 e neurons subsequent to the completion of axon guidance and establish the
  arborisation of synaptic terminals as an essential tightly regulated fea
 ture of synaptic structural consolidation.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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