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SUMMARY:Neural Circuits & Behavior Progress Report // Galina Limorenko - D
 evelopment and validation of in vitro\, in cellulo and in vivo models to e
 lucidate the roles of Tau proteoforms in regulating Tau aggregation\, seed
 ing and pathology spreading
DTSTART:20191205T093000
DTEND:20191205T103000
DTSTAMP:20260507T174011Z
UID:4c494a87f38d996208e11fea1b8f202ebc88a5ddebe4ed0e7220e523
CATEGORIES:Conferences - Seminars
DESCRIPTION:Galina Limorenko\, Prof. Lashuel's Lab\nThe microtubule-bindin
 g protein Tau is an intrinsically disordered protein\, in cells most promi
 nently associated with dynamic regulation and stabilisation of cytoskeleta
 l and mitotic microtubules. Increasing evidence points to Tau aggregation 
 and post-translational modifications\, such as truncation\, as central eve
 nts in the pathogenesis of AD and Tauopathies. Truncated Tau fragments der
 ived from AD patients’ brain and CSF have been shown to possess Tau nucl
 eating and templated seeding competency in vitro\, in cell culture and in 
 vivo models of Tauopathies. Nevertheless\, the molecular and cellular fact
 ors that trigger Tau misfolding and aggregation\, as well as which Tau spe
 cies initiate and/or drive Tau pathology and spreading in the brain remain
  unknown. In addition\, no in vitro\, cellular or animal models accurately
  recapitulate the Tau aggregation\, seeding and spreading mechanisms.\nTo 
 address these issues as a part of my project I aim to conduct a systematic
  investigation of the Tau truncation products’ role in regulating Tau ag
 gregation\, seeding and pathology spreading in vitro\, in in cellulo model
  of Tau seeding and aggregation\, and in vivo models of Tau pathology spre
 ading. On the basis that shorter fragments of Tau exhibit high aggregation
  propensity we hypothesise that the aggregation of Tau fragments could pla
 y central roles in the initiation of the aggregation of the full-length Ta
 u proteins and may even regulate the cell-to-cell propagation of Tau patho
 logy.\nDuring this seminar\, I will present the overview of the Tau invest
 igation field and methodology state of the art\, and will present the rece
 nt achievements from our laboratory of in vitro Tau protein system that mo
 st closely recapitulates the Tau fibril structures found in human brain\, 
 providing an efficient in vitro platform for Tau aggregation studies. Furt
 her\, I will outline the steps towards the development of the bona fide ce
 llular model of Tau aggregation and in vivo model of Tau pathology spreadi
 ng.\nDevelopment of efficient Tau proteoform aggregation assessment pipeli
 ne will help accelerate the identification of novel biomarkers and targets
  and pave the way for developing novel diagnostic and therapies for AD and
  non-AD tauopathies.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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