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SUMMARY:BMI Progress Reports 2020 // Prof. Ramdya's Lab: Chin-Lin Chen - U
 ncovering behavioral information sent to the brain by ascending neurons
DTSTART:20200108T121500
DTEND:20200108T130000
DTSTAMP:20260509T115733Z
UID:e9d61d49f891a1baf03e7b0bef06c2e697417e8d2ef8bd63762bf75b
CATEGORIES:Conferences - Seminars
DESCRIPTION:Chin-Lin Chen\nTo achieve coordinated movements there must be 
 a dynamic loop sending information between the descending command and asce
 nding reporting systems. The command system – the brain –\, has receiv
 ed the  most attention. However\, little is known about higher-order asce
 nding neurons (ANs) that integrate information from motor circuits. This i
 s because the tissues in which motor circuits are located were inaccessibl
 e for recording in intact and behaving animals. We recently developed an a
 pproach permitting 2-photon functional imaging of the ventral nerve cord (
 VNC) of behaving adult Drosophila melanogaster. We are thus now able to fo
 cus on the kinds of behavioral information sent to the brain. We recorded 
 activity from 75 driver lines labelling approximately 250 ANs to understan
 d the correlation between behavior and AN activity by relating the calcium
  signal to limb motion class. Our preliminary results reveal that two thir
 ds of ANs are activated during different behavioral states – walking\, g
 rooming\, and standing. One third of the ANs did not show any activity. Am
 ong responsive ANs\, about 50% encode walking. Similarly\, ANs encode spec
 ific types of foreleg grooming movements. Moreover\, we also find ANs that
  are activated during proboscis-extension during standing only\, indicatin
 g an intersection of two behavioral states. In conclusion\, these findings
  suggest that ANs do not only relay raw sensory signals but also send info
 rmation about behavioral state to the brain. 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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