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SUMMARY:Neural Circuits & Behavior Process Report // Vahid Esmaeili - Lear
 ning-induced involvement of cortical areas during a whisker-based short-te
 rm memory task
DTSTART:20190110T093000
DTEND:20190110T103000
DTSTAMP:20260408T050634Z
UID:56a8590ca30d111a9339b05847828db4312d19ffcda3f4da0b486b37
CATEGORIES:Conferences - Seminars
DESCRIPTION:Vahid Esmaeili\, Prof. Petersen's Lab\nExecution of goal-direc
 ted behaviors involves coordination of a distributed network of cortical r
 egions. How different brain areas encode different aspects of behavior and
  how these representations change upon learning remains to be elucidated. 
 To address this\, we devised a Go/No-go task in which head-fixed mice dete
 ct a brief whisker deflection to collect a reward. A visual cue signals th
 e beginning of each trial. Upon whisker stimulation\, mice need to withhol
 d licking during a post-stimulus delay until an auditory go-cue is present
 ed. This delay period separates sensory processing from action initiation\
 , allowing us to investigate which brain areas contribute to sensory detec
 tion and action planning.\nWe performed silicon probe recordings in multip
 le brain areas while Expert or Novice mice performed the task. Upon whiske
 r stimulation\, a short-latency response appeared with a sequential order 
 in primary somatosensory cortex (wS1) and secondary somatosensory cortex (
 wS2) followed by primary (wM1) and secondary motor cortex (wM2) in both Ex
 pert and Novice mice. Anterior lateral motor cortex (ALM)\, tongue/jaw mot
 or cortex (tjM1) and posterior parietal cortex (PPC) represented the whisk
 er stimulus with longer latencies and their activity bridged the delay per
 iod in Expert but not in Novice mice. ALM and tjM1 transiently signaled in
 itiation of licking earlier than other areas. Optogenetic inhibition durin
 g specific behavioral epochs revealed distinct involvement of cortical are
 as. Our data thus defines global and local entrainment of different cortic
 al areas upon learning of a short-term memory goal-directed behavior
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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