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SUMMARY:Zinc finger protein evolution against transposons and its impact o
 n mammals
DTSTART:20190315T121500
DTSTAMP:20260510T221535Z
UID:1306adec9290df00e256cba7045167b58454c520197aec3a758d3d20
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Todd Macfarlan\n\nNIH\nDivison of Intramural Research\nUni
 t on Mammalian Epigenome Reprogramming\nGenetics and Epigenetics of Develo
 pment\nThe Krüppel-associated box zinc finger protein (KRAB-ZFP) family r
 apidly amplified in response to invading transposable elements but their f
 unction in organismal development has gone largely unexplored. We determin
 ed the genomic binding sites of 61 murine KRAB-ZFPs and genetically delete
 d five large KRAB-ZFP gene clusters encoding nearly one third of mouse KRA
 B-ZFPs. We demonstrate that recently evolved mouse KRAB-ZFPs silence speci
 fic retrotransposon groups in the early embryo and block retrotransposon-b
 orne enhancers from gene activation. KRAB-ZFP cluster KO mice display no o
 vert phenotypes but display increased rates of somatic retrotransposition\
 , indicating that KRAB-ZFPs limit the mobilization of retrotransposons in
  vivo.  Our data supports an arms-race model in which many KRAB-ZFPs evol
 ve to repress retrotransposons from amplifying within the genome\, minimiz
 ing the risk of insertional mutagenesis.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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