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SUMMARY:dNTPs and maintenance of genome stability
DTSTART:20190226T171500
DTEND:20190226T181500
DTSTAMP:20260416T193659Z
UID:13bf35c38c8566372f49c042fd90933e0100eb901853731c032e9f51
CATEGORIES:Conferences - Seminars
DESCRIPTION:Professor Andrei Chabes Dept. of Medical Biochemistry and Biop
 hysics Umeå University SE 901 87 Umeå Sweden Phone: +46 73 620 5446 \nT
 he four dNTPs (dATP\, dTTP\, dCTP\, and dGTP) are the building blocks of D
 NA. A balanced supply and a correct overall concentration of dNTPs are key
  prerequisites for faithful genome replication. These requirements\, along
  with the fact that the concentrations of dNTPs fluctuate during the cell 
 cycle\, mean that the production of dNTPs must be tightly regulated throug
 h multiple mechanisms.   By introducing point mutations in the genes resp
 onsible for the production of dNTPs\, I have created different budding yea
 st and mouse models that have altered dNTP metabolism. Using these models\
 , I am investigating how imbalanced dNTP pools alter the fidelity of DNA r
 eplication and how different replication errors are recognized and repaire
 d. I will discuss how metabolic changes in the dNTP pool balance affect nu
 clear and mitochondrial DNA stability\, the development of cancer\, and ot
 her genetic disorders.
LOCATION:BCH 2218 https://plan.epfl.ch/?room==BCH%202218
STATUS:CONFIRMED
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