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SUMMARY:Developing small molecule catalysts for chemical protein degradati
 on
DTSTART:20190219T161500
DTEND:20190219T171500
DTSTAMP:20260405T201624Z
UID:1164ec3bdf8892f01d305c3e39e4f660afa9b97c3bcaa425495e4244
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Dennis Gillingham\nThalidomide became infamous in the 60
 ’s for its teratogenic effects but since then it and derivatives have be
 en rediscovered as potent drugs against myeloma. These molecules act as ca
 talysts by orchestrating the degradation of proteins important for the can
 cer. In a sense they offer a chemical approach to accomplish the same ends
  as siRNA or CRISPR/Cas9. In this talk I will discuss the how protein-degr
 ading small molecule catalysts work and describe efforts in our lab to bui
 ld a new series of such catalysts.
LOCATION:BCH 3118 https://plan.epfl.ch/?room==BCH%203118
STATUS:CONFIRMED
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