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SUMMARY:Chemical Engineering Seminar - Towards Electrogenetics: integratin
 g biofabrication\, synthetic biology\, and microelectronics
DTSTART:20190322T161500
DTEND:20190322T173000
DTSTAMP:20260510T165041Z
UID:56927ea3cba3f0ff7d532994533291f64ce5ff4aa14bc2af70fda17e
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. William E. Bentley\, Fischell Department of Bioengineer
 ing\, University of Maryland\, USA\nWe are developing tools of “biofabr
 ication” that enable facile assembly of biological components within dev
 ices\, including microelectronic devices\, that preserve their native biol
 ogical function. By recognizing that biological redox active molecules are
  a biological equivalent of an electron-carrying wire\, we have developed 
 biological surrogates for electronic devices\, including a biological redo
 x capacitor that enable bi-directional “electron” flow. We have also t
 urned to synthetic biology to provide a means to sample\, interpret and re
 port on biological information contained in molecular communications circu
 itry. Finally\, we have developed synthetic genetic circuits that enable e
 lectronic actuation of gene expression. That is\, using simple reconstruct
 ions\, one can apply voltage on an electrode and directly actuate genetic 
 responses and associated phenotypes. Cells are stimulated to swim\, make o
 ther signal molecules\, and fluoresce. This presentation will introduce th
 e concepts of molecular communication that are enabled by integrating rela
 tively simple concepts in synthetic biology with biofabrication. Our prese
 ntation will show how engineered cells represent a versatile means for med
 iating the molecular “signatures” commonly found in complex environmen
 ts\, or in other words\, they are conveyors of molecular communication.
LOCATION:BCH 2201 https://plan.epfl.ch/?room==BCH%202201
STATUS:CONFIRMED
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