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SUMMARY:Daily Light and Darkness Onset Metabolically Control Hematopoietic
  Stem Cell Function
DTSTART:20190211T121500
DTSTAMP:20261002T022038Z
UID:eed902a26e98044e263154f59222013075a793be207692d48427c1b3
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Tsvee Lapidot\, Weizmann Institute of Science\, Rehovot\
 , Israel\nDISTINGUISHED LECTURE IN BIOENGINEERING\n(sandwiches served)\n\n
 Abstract:\nHematopoietic stem and progenitor cells (HSPC) are essential fo
 r mature blood cell production\, host immunity and osteoclast mediated bon
 e turnover. When do stem cells give rise to all mature blood cells while m
 aintaining their pool and how these opposite tasks are synchronized is poo
 rly understood. Recent studies revealed that daily onset of light and dark
 ness differentially control HSPC migration and differentiation while maint
 aining their bone marrow (BM) reservoir by inducing circadian bursts of BM
  norepinephrine (NE)\, TNF and melatonin. Bone forming stromal precursors 
 are also regulated by daylight and darkness onset. The metabolic cross tal
 k between blood and bone forming stem cells which protects hematopoietic s
 tem cells from chemotherapy insult and the potential role of stress induce
 d mitochondria transfer will be presented.  These topics and their clinic
 al potential will be discussed.\n\nBio:\nEducation:\n1990-1994:   Post-D
 oc. Hospital for Sick Children\, University of Toronto\, Canada.\n1985-199
 0:   Ph.D. Weizmann Institute\, Rehovot\, IL.\n1983-1985:   M.Sc. Weiz
 mann Institute\, Rehovot\, IL.\n1980-1983:   B.Sc. The Hebrew University
 \, Jerusalem\, IL.\n\nEmployment:\n2006 - Present:   Professor\, Departm
 ent of Immunology\, Weizmann Institute.\n2001 - 2006:   Associate Profes
 sor\, Department of Immunology\, Weizmann Institute.\n1994 - 2001:   Sen
 ior Scientist. Department of Immunology\, Weizmann Institute.\n \n\n\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CANCELLED
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