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SUMMARY:Repurposing Ribosomes for Synthetic Biology
DTSTART:20190507T121500
DTEND:20190507T131500
DTSTAMP:20260916T043730Z
UID:a04172732d91b24f937964bd6549484119d5dd5a1dc8b475572e1d23
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Michael Jewett\, Northwestern University\, Evanston\, IL
  (USA)\nBIOENGINEERING SEMINAR\n\nAbstract: \nImagine a world in which
  we could adapt biology to manufacture any therapeutic\, material\, or 
 chemical from renewable resources\, both quickly and on demand. Industrial
  biotechnology is one of the most attractive approaches for addressing thi
 s need\, particularly when large-scale chemical synthesis is untenable. Un
 fortunately\, current approaches to engineering organisms remain costly 
 and slow. This is because cells themselves impose limitations on biobased 
 product synthesis. It is difficult to balance intracellular fluxes to opti
 mally satisfy a very active synthetic pathway while the machinery of the
  cell is functioning to maintain reproductive viability. Further\, chemica
 l reactions take place behind a selective barrier\, the cell wall\, which
  limits sample acquisition\, monitoring\, and direct control. In addition
 \, cells are adapted to a relatively simple chemical operating system (i.e
 .\, a few common sugars\, 20 amino acids)\, which presents researchers 
 a limited set of accessible molecules with which to work. In this prese
 ntation\, I will discuss my group's efforts to overcome these limitations
  and widen the aperture of the traditional model of biotechnology.  In o
 ne direction\, we seek to create a new paradigm for engineering biocatal
 ytic systems using cell-free biology. In another area\, we are catalyzin
 g new directions to repurpose the translation apparatus for synthetic 
 biology. Our new paradigms for biochemical engineering are enabling a d
 eeper understanding of why nature’s designs work the way they do\, as we
 ll as opening the way to novel biobased products that have been impractica
 l\, if not impossible\, to produce by other means. \n\nBio:\nMichael Jewe
 tt is the Charles Deering McCormick Professor of Teaching Excellence\, a P
 rofessor of Chemical and Biological Engineering\, and co-director of the C
 enter for Synthetic Biology at Northwestern University. He is also an Inst
 itute Fellow at the Northwestern Argonne Institute for Science & Engineeri
 ng. Dr. Jewett’s lab seeks to re-conceptualize the way we engineer compl
 ex biological systems for compelling applications in medicine\, materials\
 , and energy by transforming biochemical engineering with synthetic biolog
 y. Dr. Jewett is the recipient of the NIH Pathway to Independence Award in
  2009\, David and Lucile Packard Fellowship in Science and Engineering in 
 2011\, the DARPA Young Faculty Award in 2011\, the Agilent Early Career Pr
 ofessor Award in 2011\, the 3M non-tenured faculty grant in 2012\, the Cam
 ille-Dreyfus Teacher-Scholar Award in 2015\, the ACS Biochemical Technolog
 ies Division Young Investigator Award in 2017\, and the Biochemical Engine
 ering Young Investigator Award in 2018. He received his PhD in 2005 at Sta
 nford University and completed postdoctoral studies at the Center for Micr
 obial Biotechnology in Denmark and the Harvard Medical School.
LOCATION:CM 1 5 https://plan.epfl.ch/?room==CM%201%205
STATUS:CANCELLED
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