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SUMMARY:Gabriel Nuñez // Microbiota-Host Interactions in Health and Disea
 se
DTSTART:20190305T121500
DTSTAMP:20260510T055744Z
UID:e8262a029bc76942c3b36c43656bf0d78e919757c9415e4a87b77e41
CATEGORIES:Conferences - Seminars
DESCRIPTION:Gabriel Nuñez\, Department of Pathology and Rogel Cancer Cent
 er\, University of Michigan Ann Arbor\, Michigan\, U.S.A.\nThe mechanisms 
 that allow enteric pathogens to colonize the intestine in the presence of 
 the microbiota and how host immunity and the indigenous microbiota regulat
 e pathogen colonization remain poorly understood. Our laboratory is using 
 Citrobacter rodentium\, a mouse pathogen that models human infections by e
 nteropathogenic E. coli\, to understand the mechanisms that regulate the c
 olonization and clearance of the pathogen in the gut.  These studies have
  revealed how the pathogen colonizes and replicates successfully early dur
 ing infection and how host immunity and the indigenous microbiota cooperat
 e to eradicate the pathogen in the later stage of the infection. These stu
 dies have also revealed that Clostridia species protect the host from colo
 nization by C. rodentium and Salmonella enterica in the intestine. In addi
 tion to their protective role\, bacterial symbionts can also induce inflam
 matory disorders such as Crohn’s disease in genetically susceptible indi
 viduals. We will show and discuss new results that demonstrate that partic
 ular symbiotic bacteria can accumulate in the intestine to trigger Crohn
 ’s disease-like colitis in mice with mutations relevant to the developme
 nt of inflammatory bowel disease in humans.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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