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SUMMARY:Bioengineering neural repair in the central nervous system
DTSTART:20190306T100000
DTEND:20190306T110000
DTSTAMP:20260920T060516Z
UID:4e9cfc1377d66d5b67929111c3dca2607f25c4f7537a216c7c0aa2b0
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr Timothy O’Shea\, University of California\, Los Angeles\,
  USA.\nFollowing traumatic injury to the adult central nervous system (CNS
 )\, neural connectivity is lost and fails to spontaneously regrow. This re
 generation failure may be due to an intrinsic inability for damaged neuron
 s to regrow in the adult as well as the formation of a stromal and inflamm
 atory cell laden non-neural lesion core that is devoid of essential axon g
 rowth cues. The first part of this talk dissects the cell biology of traum
 atic CNS injury lesions and demonstrates that stimulating axons to regrow 
 after injury requires the sequential re-activation of neuronal growth capa
 city and the reintroduction of essential molecular factors not present in 
 CNS lesion compartments. The second part of the talk will outline how the 
 grafting of neural progenitor cells into CNS lesions may be used to provid
 e long-term support to stimulated axon regeneration paradigms. The last pa
 rt of the talk will describe the development of an immunohistochemical fra
 mework to evaluate the multicellular CNS foreign body response to biomater
 ials and how various properties of biomaterials can be manipulated to impr
 ove the functionality of these tools in bioengineered neural repair strate
 gies.\n\nBio\nDr. Timothy O’Shea is a Postdoctoral Fellow in Neurobiolog
 y at UCLA. He completed his PhD study in Medical Engineering and Medical P
 hysics within the collaborative Health Sciences and Technology program of 
 the Harvard Medical School and the Massachusetts Institute of Technology. 
 Tim conducted PhD thesis research with Institute Professor Robert Langer d
 eveloping injectable biomaterials to improve the delivery of reparative th
 erapies for the treatment of various central nervous system (CNS) diseases
 . At UCLA he works with Professors Michael Sofroniew (Neurobiology) and Ti
 mothy Deming (Bioengineering) developing and testing novel bioengineering 
 tools to study biological mechanisms involved in CNS injury and repair. He
  has held research fellowships from the Sir John Monash Foundation\, the S
 ociety of Chemical Industry\, the Craig H. Neilsen Foundation\, Paralyzed 
 Veterans of America and American Australian Association. His research has 
 been published in Nature\, JCI\, Cell Reports\, JACS\, Advanced Materials\
 , Biomaterials and other leading journals.\n\nVideo transmission using zoo
 m : https://epfl.zoom.us/j/9946495775\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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