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SUMMARY:Regulation of mitochondrial homeostasis by metabolism in mitochond
 ria
DTSTART:20190313T103000
DTEND:20190313T113000
DTSTAMP:20260917T054849Z
UID:1f91efb4272bb8ac1491f93df3cc2c3fb5a4518c2b3034c3a226b4c5
CATEGORIES:Conferences - Seminars
DESCRIPTION:Junxiang ZHOU Ph.D. in Chonglin Yang’s lab\, Institute of Ge
 netics and Developmental Biology (IGDB)\, Chinese Academy of Sciences  \n
 Mitochondria are central to cell homeostasis by coordinating many cataboli
 c and anabolic pathways and coupling the TCA cycle with ATP production. Ho
 wever\, it is largely unknown how aberrant metabolism affect mitochondria.
  Here we show the requirement for mitochondrial saccharopine degradation i
 n mitochondrial homeostasis and animal development\, which provides mechan
 istic and therapeutic insights for understanding and treating hyperlysinem
 ia II (saccharopinuria)\, an aminoacidopathy with severe developmental def
 ects. Besides\, we demonstrate that defective degradation of D-2HG induces
  mitochondrial damage by inhibiting the metabolism of propionate\, suggest
 ing that mitochondrial dysfunction contributes to D-2HG related metabolic 
 disorders and cancers.\n \n 
LOCATION:AI 3142 https://plan.epfl.ch/?room=AI3142
STATUS:CONFIRMED
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