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SUMMARY:BMI SEMINAR // Michele Pignatelli - Engram Cell Excitability State
  Determines the Efficacy of Memory Retrieval
DTSTART:20190410T121500
DTEND:20190410T131500
DTSTAMP:20260406T121526Z
UID:cf451e35369dcb7a409271d192e67a9baf1f28c31a75485897e4bd04
CATEGORIES:Conferences - Seminars
DESCRIPTION:Michele Pignatelli\, Massachusetts Institute of Technology\, U
 SA\nMemory exists across different time scales. Long-term memories can las
 t a lifetime\, while working memory persists for mere seconds. In between\
 , memories that are newly formed—or recently recalled—are more vivid t
 han latent ones. How does this happen? The recent development of memory en
 gram labeling technology allows a precise investigation of the processes a
 ssociated with the recall of a specific memory. Here\, we show that engram
  cell excitability is transiently increased following memory reactivation.
  This short-term increase of engram excitability enhances the subsequent r
 etrieval of specific memory content in response to cues and is manifest in
  the animal’s ability to recognize contexts more precisely and more effe
 ctively. These results reveal a hitherto unknown transient enhancement of 
 context recognition based on the plasticity of engram cell excitability. T
 hey also suggest that recall of a contextual memory is influenced by previ
 ous but recent activation of the same engram. The state of excitability of
  engram cells mediates differential behavioral outcomes upon memory retrie
 val and may be crucial for survival by promoting adaptive behavior.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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