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SUMMARY:Organelle communication - shaping metabolism in immune cells
DTSTART:20190314T140000
DTEND:20190314T150000
DTSTAMP:20260427T205922Z
UID:a456e4a0d157a95a1579b5a88302016fa10c88986569a9a4a4172698
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr Angelika Rambold Max Planck Institute of Immunobiology and 
 Epigenetics\nMounting a successful immune response is a complex and energy
 -intensive process where cells rapidly alter their migratory behavior\, pr
 oliferation and protein synthesis rates. To ensure this response\, most im
 mune cells require reprogramming of their metabolism to sustain energy sup
 ply and generate building blocks for the synthesis of macromolecules. Insi
 de cells\, such metabolic pathways are heavily sub-compartmentalized in sp
 ecialized entities: organelles. While the fact that organelles present met
 abolic hubs has long been appreciated\, emerging evidence suggests that th
 ey do not work as separate entities. Instead they form interactive networ
 ks to coordinate their function and connect metabolic sub-processes. These
  can be formed via direct communication\, where the physical contact betwe
 en organelles facilitates the exchange of nutrients. Alternatively\, indir
 ect modes of communication\, like transcriptional organelle stress program
 s can shape and coordinate the activities of one or more organelles. Our p
 revious work identified direct communication between mitochondria to drive
  memory T cell differentiation and indirect lysosomal stress signaling in 
 shaping mitochondrial TCA cycle integrity in macrophages responding to pat
 hogens. \n 
LOCATION:BSP 233 https://plan.epfl.ch/?room==BSP%20233
STATUS:CANCELLED
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