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SUMMARY:Special LMNN Seminar - Identification of an ER-resident receptor t
 yrosine kinase that regulates proteostasis
DTSTART:20190314T090000
DTEND:20190314T100000
DTSTAMP:20260916T201416Z
UID:e533a9ccfd6334e0c4696eea53eef825136da439126f0658fcc8a9ff
CATEGORIES:Conferences - Seminars
DESCRIPTION:Hesso Farhan\, Department of Molecular Medicine\, Institute of
  Basic Medical Sciences\, University of Oslo\, Norway\nNearly 70% of the e
 nergy of a eukaryotic cell is devoted to protein synthesis. Thus\, our cel
 ls have evolved a complex machinery that handles the proteome. The homeost
 atic balance of protein synthesis\, quality control\, trafficking and degr
 adation is referred to as proteostasis. Most of what we know about the reg
 ulation of proteostasis is based on how cells deal with misfolded or toxic
  proteins through a process called the Unfolded Protein Response (UPR). Th
 e main function of the UPR is to stop protein synthesis and to increase th
 e efficiency of folded and degradation. While the UPR is a fairly well und
 erstood process\, less is known about how cells deal with fluctuations of 
 folded proteins. The aforementioned responses of the UPR seem inadequate t
 o help the endoplasmic reticulum (ER) to deal with folded proteins. In my 
 talk I will show evidence that we have identified and ER-resident receptor
  tyrosine kinase that senses folded proteins and thereby regulates proteos
 tasis. I will discuss possibilities that this is part of a general respons
 e that we might call the Folded Protein Response (FPR). Finally\, I will s
 how how the FPR is relevant for understanding diseases that are characteri
 zed by changes in the load of folded proteins such as multiple myeloma. \
 n 
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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