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SUMMARY:BMI SEMINAR // Tara Keck - Synapse specific homeostatic responses 
 to sensory deprivation
DTSTART:20191016T121500
DTEND:20191016T131500
DTSTAMP:20260511T071349Z
UID:b9d6ed262fd37a6bc6f538ab0513dfc05c917cebb88241acff78a3ab
CATEGORIES:Conferences - Seminars
DESCRIPTION:Tara Keck\, Neuro\, Physiology & Pharmacology\, Div of Bioscie
 nces\, UCL\, London\, UK\nHomeostatic compensation of neural activity is n
 ecessary to prevent aberrant activity levels. Compensatory mechanisms can 
 take several forms\, including synaptic scaling\, where synaptic weights a
 re changed by an equal fraction across the spatial scale of the cell or de
 ndritic branch and in a way that is anti-correlated with the changes in ac
 tivity. Our previous work has shown that not all synapses undergo synaptic
  scaling\, but the functional properties of the affected synapses are not 
 clear. Based on studies of metaplasticity\, one prediction is that the syn
 apses that lose the most activity would have the largest increase in activ
 ity following deprivation. Here we show that the synapses that undergo com
 pensatory increases in synaptic strength following sensory deprivation are
  more strongly correlated with the activity intrinsic to the network prior
  to deprivation\, whereas the spines that received sensory input prior to 
 deprivation do not strengthen over the time course of synaptic scaling. Th
 ese results suggest that homeostatic synaptic compensation in vivo may be 
 implemented specifically in the subset dendritic spines whose inputs refle
 ct intrinsic network activity\, rather than feedforward sensory inputs. Th
 is would serve to preserve input-output relationships while regulating cor
 tical activity levels.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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