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SUMMARY:BMI SEMINAR // Rosa Cossart - All optical interrogation of develop
 ing GABAergic circuits in vivo
DTSTART:20210317T121500
DTEND:20210317T131500
DTSTAMP:20260510T105739Z
UID:4c5553563facc4dfbf29138ad1ef1016d2c4b6e901898b8bd04fd703
CATEGORIES:Conferences - Seminars
DESCRIPTION:Rosa Cossart\, Mediterranean Neurobiology Institute\, INMED - 
 INSERM U901\,  Faculté de Médecine\, Aix-Marseille Université\, Marsei
 lle\, France\nThe developmental journey of cortical interneurons encounter
 s several activity-dependent milestones. During the early postnatal period
  in developing mice\, GABAergic neurons are transient preferential recipie
 nts of thalamic inputs and undergo activity-dependent migration arrest\, w
 iring and programmed cell-death. But cortical GABAergic neurons are also s
 pecified by very early developmental programs. For example\, the earliest 
 born GABAergic neurons develop into hub cells coordinating spontaneous act
 ivity in hippocampal slices.\nDespite their importance for the emergence o
 f sensory experience\, their role in coordinating network dynamics\, and t
 he role of activity in their integration into cortical networks\, the coll
 ective in vivo dynamics of GABAergic neurons during the neonatal postnatal
  period remain unknown. Here\, I will present data related to the coordina
 ted activity between GABAergic cells of the mouse barrel cortex and hippoc
 ampus in non-anesthetized pups using the recent development of all optical
  methods to record and manipulate neuronal activity in vivo.  I will show
  that the functional structure of developing GABAergic circuits is remarka
 bly patterned\, with segregated assemblies of prospective parvalbumin neur
 ons and highly connected hub cells\, both shaped by sensory-dependent proc
 esses.\n 
LOCATION:Online
STATUS:CONFIRMED
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