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SUMMARY:BMI SEMINAR // Rosa Paolicelli - Microglial dysfunction in the pat
 hogenesis of neurodegeneration
DTSTART:20191218T133000
DTEND:20191218T143000
DTSTAMP:20260407T171833Z
UID:3ed8620b82915e1e73ca22ea7ba3d21d692fc2f9ce15f39c8be08c45
CATEGORIES:Conferences - Seminars
DESCRIPTION:Rosa Paolicelli\, Department of Physiology\, Faculty of Biolog
 y and Medicine\, UNIL\, CH\nMicroglia are the tissue-resident macrophages 
 of the central nervous system and thus represent the first line of defense
  against pathogens or changes in the brain homeostasis.\nIn the last decad
 e\, several novel physiological functions have been described for microgli
 a\, besides their immune roles\, ranging from promoting neurogenesis\, to 
 surveying the brain parenchyma\, and providing trophic support to neurons 
 across the entire lifespan. During early brain development microglia also 
 play critical roles in remodeling synaptic connections and thus\, in shapi
 ng neural circuits\, with defective synaptic pruning leading to long-term 
 brain connectivity and behavioral deficits.\nSynapse loss is the major cor
 relate of cognitive impairment in neurodegenerative diseases\, and recent 
 findings indicate that microglia can also be responsible for synapse loss 
 in neurodegeneration. Here we will discuss the multiple roles of microglia
  in neurodegenerative diseases\, and will provide evidence that dysfunctio
 nal microglia can be causally implicated in the pathogenesis of neurodegen
 eration.\n\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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