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SUMMARY:Disinhibitory amygdala microcircuits for aversive learning
DTSTART:20190326T100000
DTEND:20190326T110000
DTSTAMP:20260510T054621Z
UID:960128ddbfad7ecaf0fed7eba1fee24317f13f06821ac412e95e28c1
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr Sabine Krabbe\, Friedrich Miescher Institute for Biomedical
  Research\, CH.\nLearning and memory are fundamental neuronal processes th
 at are essential for behavioural adaptations in an ever-changing environme
 nt. Mechanisms of memory formation are critically shaped by dynamic change
 s in the balance of excitatory and inhibitory neuronal circuit elements. A
 lthough local inhibitory interneurons only represent a minority of the cel
 ls in most brain areas\, they can tightly regulate the activity and plasti
 city of excitatory projection neurons in a spatially and temporally precis
 e manner. Using fear conditioning as a model system for associative learni
 ng\, we dissect the functional role of distinct interneuron subtypes in am
 ygdala circuits for sensory processing and memory formation. In this talk\
 , I will demonstrate how we combine deep-brain imaging and optogenetics in
  freely behaving mice with neural circuit tracing approaches and electroph
 ysiology to address interactions of distinct amygdala inhibitory interneur
 ons\, and how this disinhibitory interplay affects plastic changes of neig
 hbouring excitatory neurons and thus gates learning.\n\nBio\nSabine Krabbe
  studied Human Biology at the University of Marburg and received her PhD i
 n Neurophysiology in 2012. For her postdoctoral work\, Sabine joined the l
 aboratory of Andreas Lüthi at the Friedrich Miescher Institute for Biomed
 ical Research in Basel\, where she focussed her research on the dissection
  of inhibitory amygdala microcircuits in fear learning and anxiety using a
  combination of deep-brain imaging\, electrophysiology and optogenetic app
 roaches. In February 2018\, Sabine became a visiting scientist at HHMI Jan
 elia Research Campus. Hosted by Scott Sternson’s laboratory\, she addres
 ses how genetically-defined amygdala neurons encode information during dif
 ferent behavioural and metabolic states by employing a novel spatial trans
 criptomic approach.\n\nVideo transmission using zoom : https://epfl.zoom.u
 s/j/9946495775
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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