BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:BMI SEMINAR // Laura Cancedda - Targeting aberrant Cl- homeostasis
  in Down syndrome to design innovative therapeutic approaches
DTSTART:20191002T121500
DTEND:20191002T131500
DTSTAMP:20260510T141909Z
UID:e82328336eedbfd0d988e1c2ad74ca1a8be6a34019325487a596dd8c
CATEGORIES:Conferences - Seminars
DESCRIPTION:Laura Cancedda\, The Italian Institute of Technology\, Genoa\,
  Italy\nDown syndrome (DS) is the most frequent genetic cause of intellect
 ual disability. A large body of literature demonstrated that altered GABAe
 rgic transmission through Cl−- permeable GABAAreceptors considerably con
 tributes to learning and memory deficits in DS mouse models. In particular
 \, we have demonstrated that intracellular Cl concentration is impaired in
  DS mice due to upregulation of the Cl− importer NKCC1. Notably\, NKCC1
  inhibition by the FDA-approved diuretic bumetanide restores Cl homeostasi
 s\, synaptic plasticity and hippocampus-dependent memory in adult DS mice.
  Based on these findings\, a pilot clinical trial will soon start on adul
 t individuals with DS. Yet\, there are open issues related to Cl- homeost
 asis and NKCC1 inhibition that\, if addressed will provide new knowledge i
 nto DS molecular mechanisms and will offer a larger scientific background 
 for designing future clinical trials. In this talk\, I will summarize all 
 findings from our laboratory on DS\, and show preliminary results we recen
 tly collected on some of these open issues.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR