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SUMMARY:Roles of ZRANB3 in replication stress response
DTSTART:20190507T161500
DTEND:20190507T171500
DTSTAMP:20260314T205355Z
UID:308b0c96d43a09f507c11f5ce3d2c65b3b879073b7aa4a9390259087
CATEGORIES:Conferences - Seminars
DESCRIPTION:Professor Dragana Ahel  (University of Oxford)\nThe maintenan
 ce of complete and undamaged genome is critical for survival. However\, ge
 nomic stability is continually challenged by various assaults from the end
 ogenous and exogenous sources. One of the major threats to genome stabilit
 y is the “replication stress”\, caused by events that impede smooth pr
 ogression of DNA replication. Cellular responses to replication stress inv
 olve PCNA\, a processivity factor for eukaryotic DNA polymerases. PCNA int
 eracts with an impressive collection of various protein factors\, among wh
 ich are structure-specific nucleases. We investigated the roles of an unus
 ual endonuclease ZRANB3 at the cellular\, biochemical and structural level
 . Our data provide new molecular insights into the replication stress resp
 onse and suggest a functional link between ZRANB3 and cancer.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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