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SUMMARY:Active Forces and Stresses in Living Matter
DTSTART:20190401T090000
DTSTAMP:20261002T033657Z
UID:3e3b9aa69d78ca759357578f61e2d5db9f3b441278c15acbd2314042
CATEGORIES:Conferences - Seminars
DESCRIPTION:Pierre Ronceray\, Ph.D.\, Princeton University\, Princeton\, N
 J (USA)\nBIOENGINEERING SEMINAR\n \nAbstract:\nA key feature of living sy
 stems is their ability to consume chemical energy to actively generate the
  forces they use to move and change shape. These forces are typically gene
 rated at the nanometer scale by motor proteins\, and transmitted to larger
  scales by networks of fibers. I will first discuss how these forces emerg
 e from Brownian noise at the sub-micron scale. From an observer's point of
  view\, there is a fundamental bound to the amount of information that can
  be recovered by monitoring the dynamics of such systems. I will propose a
  practical method\, Stochastic Force Inference\, that efficiently utilizes
  this limited information to reconstruct force fields and infer dissipativ
 e currents in Brownian systems. Moving to a larger scale\, I will then dis
 cuss the transmission of these active forces through the cytoskeleton and 
 the extracellular matrix. I will show how the nonlinear mechanical propert
 ies of these biopolymers crucially affect force transmission by selecting 
 and amplifying contractile stresses. We experimentally confirm these resul
 ts using a novel stress measurement technique\, Nonlinear Stress Inference
  Microscopy.\n\nBio:\n2016–current    Postdoctoral scholar\, Princeton
  Center for Theoretical Science\, Princeton University\, Princeton\, NJ\, 
 USA\n2013–2016   Ph. D. in Theoretical Physics\, Université Paris-Sud
 \, Paris\, France\n2011–2012   M.S. summa cum laude in Theoretical Phy
 sics\, École Normale Supérieure\, Paris\, France\n2009–2011   B.S. s
 umma cum laude in Physics\, École Normale Supérieure\, Paris\, France\n2
 009–2010   B.S. magna cum laude in Mathematics\, École Normale Supéri
 eure\, Paris\, France\n\n\nZoom link for attending remotely:  https://ep
 fl.zoom.us/j/978102563
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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