BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:BMI SEMINAR  //  Fritjof Helmchen - Neocortical dynamics during se
 nsory discrimination behavior
DTSTART:20191009T121500
DTEND:20191009T131500
DTSTAMP:20260502T074819Z
UID:24d847ce67ce03992844e268f59c1e6fb080886f9af641a73a9aeb00
CATEGORIES:Conferences - Seminars
DESCRIPTION:Fritjof Helmchen\, Brain Research Institute\, University of Zu
 rich\, CH\nThrough the combination of in vivo optical imaging and chronic 
 expression of genetically encoded calcium indicators it is now feasible to
  directly 'watch' neuronal population dynamics in the neocortex of awake\,
  head-restrained mice during specific behaviors. Here\, I will present res
 ults from calcium imaging experiments in mouse neocortex while the animals
  perform whisker-based or auditory sensory discrimination tasks. We used w
 ide-field calcium imaging to resolve spatiotemporal activation patterns ac
 ross large parts of the neocortex during individual trials. We also chroni
 cally monitored cortical dynamics over weeks and across task learning. We 
 observed wide-spread\, coordinated activation of multiple cortical areas\,
  which correlated with various behavioral aspects such as whisking\, body 
 movements\, and licking. In particular\, we identified highly distinct pat
 terns of persistent cortical activity during a short-term memory phase\, w
 hich were contingent of the animal’s behavior (active versus passive). W
 e also found that posterior parietal cortex (PPC) presumably acts as a rou
 ting hub\, with distinct subdivisions being activated for tactile versus a
 uditory discriminations. During learning we identified two salient phases 
 framing the effective learning period\, which in particular reorganized th
 e signal flow through posterior association areas\, including PPC. Our res
 ults contribute to the understanding of the principles of large-scale acti
 vation patterns supporting sensory discrimination and of how these pattern
 s emerge during learning.\nThrough the combination of in vivo optical imag
 ing and chronic expression of genetically encoded calcium indicators it is
  now feasible to directly 'watch' neuronal population dynamics in the neoc
 ortex of awake\, head-restrained mice during specific behaviors. Here\, I 
 will present results from calcium imaging experiments in mouse neocortex w
 hile the animals perform whisker-based or auditory sensory discrimination 
 tasks. We used wide-field calcium imaging to resolve spatiotemporal activa
 tion patterns across large parts of the neocortex during individual trials
 . We also chronically monitored cortical dynamics over weeks and across ta
 sk learning. We observed wide-spread\, coordinated activation of multiple 
 cortical areas\, which correlated with various behavioral aspects such as 
 whisking\, body movements\, and licking. In particular\, we identified hig
 hly distinct patterns of persistent cortical activity during a short-term 
 memory phase\, which were contingent of the animal’s behavior (active ve
 rsus passive). We also found that posterior parietal cortex (PPC) presumab
 ly acts as a routing hub\, with distinct subdivisions being activated for 
 tactile versus auditory discriminations. During learning we identified two
  salient phases framing the effective learning period\, which in particula
 r reorganized the signal flow through posterior association areas\, includ
 ing PPC. Our results contribute to the understanding of the principles of 
 large-scale activation patterns supporting sensory discrimination and of h
 ow these patterns emerge during learning.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR