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SUMMARY:MEchanics GAthering -MEGA- Seminar: Talk1 - Non-toxic broad-spectr
 um anti-viral virucidal nano-materials\; Talk2 - Particle size segregation
  and rheology interplay in dense granular flows
DTSTART:20190411T161500
DTEND:20190411T173000
DTSTAMP:20260527T215930Z
UID:0463b118e616be1012990cb2e0cf655a2e74fd41dcaa431089a8f5b7
CATEGORIES:Conferences - Seminars
DESCRIPTION:Matteo Gasbarri\, SUNMIL\, EPFL & Tomás Palacios\, LHE\, E
 PFL\nNon-toxic broad-spectrum anti-viral virucidal nano-materials by Matt
 eo Gasbarri\, SUNMIL\, EPFL\nDespite the development of vaccines and anti
 virals\, viruses are still a primary source of harm for humans. The recent
  outbreaks of pandemic such as Ebola or the percentages of people infected
  by contagious diseases such as HSV\, HIV\, influenza\, show the urgency o
 f different and efficient solutions against viruses. Recently\, our group 
 has demonstrated a novel approach to fighting viruses:  antiviral nanomat
 erials that are broad-spectrum and non-toxic. The key feature of these nan
 omaterials is their capability of inhibiting viral infection in an irrever
 sible way (i.e. with a virucidal mechanism). To the best of our knowledge 
 these compounds were the first non-toxic virucidal nanomaterials. In this 
 talk\, the design rules to achieve such virucidal drugs will be showed alo
 ng with the hypothesis on their mechanism of action. Indeed\, the translat
 ion of this concepts on different nanomaterials will be discussed.\n\nPart
 icle size segregation and rheology interplay in dense granular flows by T
 omás Palacios\, LHE\, EPFL\nParticle-size segregation is produced when b
 ulk grains\, under the action of a mechanical force\, sort themselves by t
 heir sizes. Most natural granular flows are gravity-driven\, therefore the
 y are subjected to basal shear stress\, which produces relative movement b
 etween particle layers. Small grains are more likely to fall through the v
 oids generated by larger particles displacement\, generating the rising of
  the latter. Even though experimental and numerical evidence shows that la
 rge size ratios between small and large particles exacerbate segregation\,
  a clear relation between segregation fluxes and size ratios is still miss
 ing. Rheological models (e.g. mu(I) rheology) usually consider a character
 istic length for the grains but are unable to assess the role of particle-
 size segregation in bidisperse granular flows. My ongoing work seeks to pr
 ovide a link between the mechanical response of dense granular flows and p
 article-size segregation. Three experimental setups are used to provide ev
 idence on what drives the segregation of particles by their sizes and how 
 it relates to the rheology or internal friction of the granular bulk. Expe
 rimental results show different segregation rates for identical external f
 orcings under different particle-size ratios. Preliminary results highligh
 t the internal frictional adaptation induced by particle-size segregation.
  Apparently\, size segregation is a result of imbalanced pressure distribu
 tion that induces dilation and shear rate within the bulk. The higher the 
 size ratio\, the more imbalanced this distribution\, the faster large grai
 ns move up.
LOCATION:MED 2 2423 https://plan.epfl.ch/?room=MED22423
STATUS:CONFIRMED
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