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SUMMARY:Minority Reporting: Tools that crack unconventional signaling code
 s
DTSTART:20190523T171500
DTEND:20190523T190000
DTSTAMP:20260416T051122Z
UID:a240cf72eec990b698df3518009576fe516f025f8e5bc22d2fa54eee
CATEGORIES:Inaugural lectures - Honorary Lecture
DESCRIPTION:Prof. Yimon Aye\, ISIC - Inaugural Lecture\nTo coordinate resp
 onses and maintain fitness\, different functional units within the cell mu
 st communicate. Such dialog often occurs through small-molecule mediators.
   But just as words can vary in meaning\, depending on context\, locale\
 , and language\, small-molecule chemical signals are varied\, and can trig
 ger manifold responses that require context to be understood. I will prese
 nt how we have engineered multifunctional tools that can dissect some of t
 he most challenging cellular communication networks. I will highlight our 
 recent discovery underlying how the replication machinery is repurposed by
  a native chemical signal to promote tumor suppression (2018 Nature Chemic
 al Biology)\, and how reactive native chemical signals—once thought to b
 e too highly promiscuous to convey a message—pick out precise protein ta
 rgets to regulate cell survival (2017 Nature Chemical Biology). I will sh
 ow how such processes can be used for cancer-subtype specific cell killing
  in culture and in mice.\nInscription Requise\nhttps://go.epfl.ch/yimonaye
 \n\nBio:  Born and raised in Burma\, Yimon Aye achieved her undergraduate 
 degree in Chemistry at the University of Oxford (UK) and PhD degree in Phy
 sical Sciences at Harvard University (USA). She received her postdoc train
 ing in Life Sciences at MIT (USA) as a Damon Runyon cancer research fellow
 . In her independent career that began mid-2012\, Yimon Aye set out to und
 erstand the detailed mechanisms of electrophile signaling. This impetus cu
 lminated in the development of “REX” technologies (T-REX™ delivery a
 nd G-REX™ profiling). In a parallel research program\, she studies pathw
 ays involved in genome maintenance and nucleotide signaling\, including th
 e mechanisms of anticancer drugs in clinical use. In Autumn 2018\, she and
  her team members established the Laboratory of Electrophiles and Genome O
 peration (LEAGO) at EPFL\n\n 
LOCATION:CE 1 3 https://plan.epfl.ch/?room==CE%201%203
STATUS:CONFIRMED
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