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SUMMARY:Biofilm formation by the Gram-positive soil bacterium Bacillus sub
 tilis
DTSTART:20190507T121500
DTSTAMP:20260429T004252Z
UID:9b2679814f29d496dbf5c9b829427e38507122e6d4dd369ddf68c821
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Nicola Stanley-Wall\, School of Life Sciences\, Universi
 ty of Dundee\, UK\nBiofilms formed by the Gram-positive soil-dwelling bact
 erium Bacillus subtilis manifest as architecturally complex\, hydrophobi
 c communities on an air-agar interface. Both the structure and the hydroph
 obicity of the biofilm are the consequence of the cells producing a prote
 ctive extracellular matrix. The B. subtilis biofilm matrix comprises fi
 bres formed by the secreted protein TasA\, an extracellular polysaccharide
 \, and a secreted protein BslA. Together the matrix components surround an
 d protect the resident cells from environmental stress. I will overview th
 e remarkable properties of the proteins in the biofilm matrix that have b
 een uncovered through a cross discipline collaboration. For example we hav
 e found that BslA is a bifunctional protein with roles in both biofilm hy
 drophobicity and structuring. I will move on to highlight the identificati
 on of growth arrest as a distinct stage of biofilm formation and talk abou
 t an new role for a molecule called pulcherrimin in stopping expansion of 
 the biofilm. 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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