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SUMMARY:A Network of Lipid-Transfer Proteins at the Crossroads between Met
 abolism and Signalling
DTSTART:20190502T101500
DTEND:20190502T110000
DTSTAMP:20260916T080859Z
UID:1534aae19883e99deb15336b4587fc80d0e05ec074275bcff482eb20
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Anne-Claude Gavin\, University of Geneva (CH)\nBIOENGINE
 ERING SEMINAR\n \nAbstract:\nLipid metabolism attracts much attention owi
 ng to the pleiotropic roles of lipids and their roles in human pathologies
 . This interest motivates growing efforts dedicated to cataloguing the lip
 idome. All aspects of lipid function rely on their heterogeneous distribut
 ion in living systems and the formation of molecular signatures that defin
 e organelle membranes or microdomains. Lipid metabolism – and its associ
 ated disorders – needs to be understood in the context of this functiona
 l\, three-dimensional organization.\n\nWe developed systematic approaches 
 for lipid biology\, integrating proteomics\, lipidomics\, microfluidics an
 d bioinformatics. Understanding how cell signaling – and many biological
  functions – can be modulated by discrete changes in the chemical proper
 ties of cellular membranes and how this affects the switching behavior of 
 specific signaling lipids represents our first research interest. Many lip
 ids have signaling functions and form molecular signatures that are read b
 y specialized lipid-binding domains on effector – the so-called (and sti
 ll elusive) “lipid code”. We discovered that discrete changes in speci
 fic lipid concentrations or in the collective properties of all lipids in 
 different membranes affect the functioning and efficiency of downstream si
 gnaling. This has broad implications for human health\, as 60% of all drug
  targets reside in biological membranes. Another research interest concern
 s the study of the mechanisms involved in the creation and maintenance of 
 lipid gradients in eukaryotic cells. An emerging player in these processes
  is a group of disease-associated proteins known as lipid-transfer protein
 s (LTPs). They spatially organize lipids and connect lipid metabolic pathw
 ays that are distributed across distinct organelles\, but our knowledge of
  these transport mechanisms remains fragmented. I will present a number of
  new large-scale biochemical methods designed to systematically characteri
 ze the pathways of LTP-mediated lipid movement.\n\nBio:\nAnne-Claude Gavin
  grew up in Switzerland and received her M.Sc. and Ph.D. from the Faculty 
 of Science of the University of Geneva. After her doctorate in 1992\, she 
 did a post-doctoral internship at the European Molecular Biology Laborator
 y (EMBL) in Heidelberg\, Germany. Her research interest concerned the stud
 y of the signaling events that regulate of the progression of the cell cyc
 le. She then joined a start-up company\, Cellzome in Heidelberg\, as a fou
 nding Scientist and Director of the Molecular and Cellular Biology Departm
 ent. After 5 years\, she started her own research group at EMBL\, first as
  group leader and then a senior scientist. During these periods\, she esta
 blished a research programme that aims at the development of systems biolo
 gy approaches (integrating proteomics\, lipidomics\, microfluidics and bio
 informatics) and the characterization of cellular networks important for h
 uman pathologies\, with strong research focus on lipid metabolism and biol
 ogical membrane homeostasis. This work has received wide recognition in th
 e field\, including highly cited papers and many follow up studies. In 201
 4\, she was appointed a member of EMBO. Her work on lipid metabolism\, lip
 id transport mechanisms and their disfunctions in certain human pathologie
 s led her to be appointed Full Professor\, Chair Louis Jeantet\, in 2019\,
  et the University of Geneva. Since 2019\, Anne-Claude Gavin has been a pa
 rtner of the NCCR module\, "Chemical Biology". Anne-Claude has given multi
 ple invited talks at international conference\, co-organized several inter
 national conferences\, co-authored more than 80 peer-reviewed papers - amo
 ng them 11 were published in Nature\, Cell and Science - accumulating more
  than 10’000 citations. She frequently serves as journal reviewer and is
  an editorial board member of  Molecular & Cellular Proteomics.\n\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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