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SUMMARY:Regulation of immune tolerance to the intestinal microbiota
DTSTART:20190528T121500
DTSTAMP:20260916T011724Z
UID:4dbc85e014093f691d9b570adaf8b46207cadf6df33476d13a00b433
CATEGORIES:Conferences - Seminars
DESCRIPTION:Caspar Ohnmacht\, Centre for Allergy and Environment\, Technic
 al University and Helmholtz Zentrum\, Munich\nThe host and the symbiotic m
 icrobiota within the intestine live in close association with each other. 
 Setting up this symbiosis requires mutiple regulatory circuits from both t
 he host and the microbiome side. Particularly\, adaptive immunity includin
 g T cells need to be tolerized to prevent constant immune activation upon 
 recognition of harmless microbes. We have identified one of the key cell t
 ypes mediating this immune tolerance\, namely the so-called ROR(γt)+ reg
 ulatory T cells. These cells are induced locally within the intestinal tra
 ct and are critical to induce oral tolerance and regulate inflammatory bow
 el disease as well as type 2 immune disorders\, e.g. allergies. Both micro
 bial factors and host pathways affecting the differentiation of ROR(γt)+
  Tregs and therefore intestinal homeostasis will be discussed. Furthermor
 e this concept opens the way for the identification of microbial 'dysbiosi
 s' without the need to fully characterize complex microbial communities. 
 \n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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