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VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Cardiac fibrillation : an interdisciplinary puzzle
DTSTART:20190527T092000
DTSTAMP:20260307T133933Z
UID:1da4b05f4df473b0761d9d17088c473bb6cd11e88f21e2559f6dc4b0
CATEGORIES:Conferences - Seminars
DESCRIPTION:Guillaume Attuel\nCardiac fibrillation affects the atria or th
 e ventricles and\, in both cases\, poses major challenges to public health
  management. Atrial fibrillation is the predominant cause of embolic strok
 e while ventricular fibrillation is another word for sudden cardiac death.
  The medical community of cardiac electrophysiologists consider cardiac fi
 brillation as a disease of known cause but of unknown trigger\, the target
 ing of which solves the riddle by a combined therapy of anti-arrhythmic dr
 ugs and catheter ablation.\nHowever the rate of failure is in fact much hi
 gher than success. In a recent work (10.3389/fphys.2017.01139 and 10.3389/
 fphys.2019.00480)\, we have provided evidence and modeling which seem to c
 lash with the accepted wisdom. Reviewing historical concepts\, I will outl
 ine the difficulty to assess the random multifractal dynamics revealed in 
 recordings of the electrical activity of fibrillating human hearts without
  questioning the conducting substrate. In this respect\, I will present a 
 cardiac excitable cell network modeling of abnormal capacitive charging at
  the electrical synapses (gap junction channels)\, which accounts quantita
 tively well for the observed dynamical property in a specific region of th
 e heart. The model implies that bits of information in beat recording have
  been missed so far\, profoundly impacting their interpretation. To be val
 idated\, those new observations and modeling raise a number of challenges 
 that span various aspects that I will discuss\, such as protein expression
  and transport in cells\, or front propagation in random media. They also 
 open avenues for the discrimination of classes of diseases that underlie c
 ardiac fibrillation as only a symptom.
LOCATION:BSP 727 https://plan.epfl.ch/?room==BSP%20727
STATUS:CONFIRMED
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