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SUMMARY:T Cells Sans Frontières
DTSTART:20190603T110000
DTSTAMP:20260407T163924Z
UID:eab4a72a052e6a62f368276a7e6f689b224ce51aec62de4ece1edea6
CATEGORIES:Conferences - Seminars
DESCRIPTION:Carolyn King\, Department of Biomedicine\, University of Basel
 \nActivated CD4 T cells have the remarkable ability to differentiate into 
 many different types of effector subsets. This diversification is required
  for the generation of specialized and pathogen appropriate T cell respons
 es\, as well as long-lived and protective memory T cells. Although CD4 mem
 ory T cells are clearly important to control various infections (i.e. tube
 rculosis)\, vaccines targeting the induction of polyfunctional memory cell
 s have had only limited success. In some cases\, CD4 memory T cells can al
 so induce host detrimental effects\, for example during chronic viral infe
 ction or after organ transplantation. We hypothesize that these divergent 
 effects are dependent on heterogeneity within the CD4 memory T cell compar
 tment\, the plasticity of these cells following recall\, and their localiz
 ation relative to other cells or environmental signals. Thus\, a major goa
 l of our work is to elucidate the specific factors regulating CD4 memory T
  cell diversification and their relationship to host immunity. We are usin
 g several infection models as well as complementary microscopy approaches 
 to assess the dynamics and flexibility of T cell differentiation.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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