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PRODID:-//Memento EPFL//
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SUMMARY:Serial single molecule electron diffraction imaging: A Journey
DTSTART:20190619T161500
DTEND:20190619T171500
DTSTAMP:20260407T020808Z
UID:1d0c18eb534e36692b5f7d3109ad56fb40e0a5ab857345adcfa64f00
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Wei Kong\nOregon State University \, USA\nSerial single 
 molecule electron diffraction imaging (ss-EDI) relies on signal accumulati
 on of molecules oriented in the same direction to solve the problem of cry
 stallization in atomic structure determination of molecules and nanocluste
 rs. A critical issue in this approach is substrate free molecular orientat
 ion.  Electric field induced alignment and/or orientation relies on effec
 tive suppression of thermal rotation\, thus superfluid helium droplets wit
 h an equilibrium temperature of 0.4 K offer the desired cooling effect.  
 However\, the droplet matrix also introduces a diffraction background.  H
 ere we demonstrate the practicality of electron diffraction of single mole
 cules inside superfluid helium droplets.  By taking advantage of velocity
  slip of a pulsed droplet beam\, selective diffraction from monomers\, dim
 ers and even larger clusters can be obtained. To further extend this appro
 ach to macromolecular ions and nanoclusters\, we also demonstrate doping o
 f ions from electrospray ionization into superfluid helium droplets. Altho
 ugh the ultimate demonstration of ss-EDI is still steps away\, steady effo
 rts are being made toward the final goal.\nSerial single molecule electron
  diffraction imaging (ss-EDI) relies on signal accumulation of molecules o
 riented in the same direction to solve the problem of crystallization in a
 tomic structure determination of molecules and nanoclusters. A critical is
 sue in this approach is substrate free molecular orientation.  Electric f
 ield induced alignment and/or orientation relies on effective suppression 
 of thermal rotation\, thus superfluid helium droplets with an equilibrium 
 temperature of 0.4 K offer the desired cooling effect.  However\, the dro
 plet matrix also introduces a diffraction background.  Here we demonstrat
 e the practicality of electron diffraction of single molecules inside supe
 rfluid helium droplets.  By taking advantage of velocity slip of a pulsed
  droplet beam\, selective diffraction from monomers\, dimers and even larg
 er clusters can be obtained. To further extend this approach to macromolec
 ular ions and nanoclusters\, we also demonstrate doping of ions from elect
 rospray ionization into superfluid helium droplets. Although the ultimate 
 demonstration of ss-EDI is still steps away\, steady efforts are being mad
 e toward the final goal.\n 
LOCATION:BCH 2201 https://plan.epfl.ch/?room==BCH%202201
STATUS:CANCELLED
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