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SUMMARY:Changing Neighbours: Bone Marrow Remodeling during Ageing and Age-
 Related Myeloproliferative Diseases
DTSTART:20190617T121500
DTSTAMP:20260407T064510Z
UID:492812f789084bd707a446c03ccbf59c6b37120b32332e137d0a2949
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Simón Méndez-Ferrer Wellcome Trust-Medical Research Coun
 cil Cambridge Stem Cell Institute and Department of Haematology\, Universi
 ty of Cambridge\, and NHS Blood and Transplant\, Cambridge Biomedical Camp
 us\, Cambridge (UK)\nBIOENGINEERING SEMINAR\n(sandwiches served)\n \nAbst
 ract:\nHaematopoietic stem cells residing in the bone marrow accumulate du
 ring ageing but are functionally impaired. However\, the role of haematopo
 ietic-stem-cell-intrinsic and -extrinsic ageing mechanisms remains debated
 . Myeloid malignancies are more frequent in the elderly\, but whether chan
 ges in the aged haematopoietic stem cells and/or their microenvironment pr
 edispose to these malignancies remains unclear. In the first part of the t
 alk\, unpublished evidence will be presented indicating that the bone marr
 ow microenvironment promotes haematopoietic ageing\, both during physiolog
 y and in premature\, pathological haematopoietic ageing\, which can be imp
 roved by targeting the microenvironment. In the second part of the talk\, 
 preliminary data will be discussed supporting the concept that the interac
 tion of mutant haematopoietic stem cells with different bone marrow niches
  can influence the progression of myeloid malignancies driven by the same 
 oncogenic pathway. Together\, these results endorse the microenvironment a
 s a complementary therapeutic target in age-related myeloid malignancies.\
 n  \nBio:\nMéndez-Ferrer is currently Reader at the University of Cambr
 idge\, a PI of NHS-Blood and Transplant and the Wellcome Trust-Medical Res
 earch Council Cambridge Stem Cell Institute (UK). He received his B.S. deg
 ree in Seville (Spain) from 1999 and a Ph.D. degree in the same city from 
 2004. He did his postdoctoral work at the Icahn School of Medicine at Moun
 t Sinai\, New York. Méndez-Ferrer has discovered a connection with bone m
 arrow\, the brain and other systemic signals which controls the behaviour 
 of blood stem cells. His research has contributed to the dissection of the
  "niches" in which stem cells reside and to the understanding of the role 
 of these niches in the development of myeloproliferative diseases.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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