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SUMMARY:Special LMNN Seminar - Where does Parkinson’s disease start and 
 how does it spread in the brain ?
DTSTART:20190704T100000
DTEND:20190704T110000
DTSTAMP:20260529T001111Z
UID:94891442d10335cfd6bafd8893118b7cb5e670365b4b0ce94a7b9a7d
CATEGORIES:Conferences - Seminars
DESCRIPTION:Maurice A Curtis\, Head of the Department of Anatomy and Medic
 al Imaging at the University of Auckland\, New Zealand\, and Deputy Direct
 or of the Neurological Foundation Human Brain Bank\nSix to ten years befor
 e a person visits the doctor with the cardinal features of Parkinson’s d
 isease (PD\; paucity of movement and rigidity) they will usually have lost
  their sense of smell. Pathologically\, PD is characterised by the accumul
 ation of α-syn in various brain regions and a loss of dopamine cells in t
 he substantia nigra. But\, the olfactory bulb is one of the first brain re
 gions affected by the accumulation of α-syn. Apparently\, the majority of
  α-syn accumulates in neurons of the anterior olfactory nucleus in the ol
 factory bulb. α-syn spreads from the anterior olfactory nucleus to to the
  olfactory tract\, anterior olfactory cortex and then into the substantia 
 nigra. Thus\, understanding the early changes in the olfactory bulb could 
 be key in identifying early targets for slowing or stopping the progressio
 n of PD-related brain changes before the cardinal features appear. To this
  end we have performed studies on ethically sourced normal and PD human ol
 factory bulbs with a focus on characterising glomerular changes\, measurin
 g metal accumulation and identifying which cell types accumulate α-syn. T
 o study glomeruli we have performed 3D reconstructions of whole human olfa
 ctory bulbs and have identified a ventral glomerular deficit and aberrant 
 placement of many glomeruli in PD. To study metal accumulation we used ind
 uctively coupled plasma mass spectrometry\, which demonstrated the regiona
 l distribution of metals in the bulb and in particular showed increased ir
 on and sodium in the olfactory bulb in PD. Finally we have examined the ce
 ll types in which α-syn accumulates in the bulb. Our studies reveal that 
 in PD bulbs\, neurons\, glia\, pericytes and microglia all express α-syn 
 in all cases studied. The results of these studies and implications for PD
  will be discussed.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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