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SUMMARY:[ U.S. DEPARTMENT OF DEFENSE - Reconstructive Transplant Research 
 Program Investigator-Initiated Research Award | Research funding ]
DTSTART;VALUE=DATE:20190717
DTSTAMP:20260506T080557Z
UID:ef8e27032a49daa1e5798d90b76c33d329e5421b0dbfb170eee7f23c
CATEGORIES:Call for proposal
DESCRIPTION:Aim: Through the Congressionally Directed Medical Research Pro
 gram (CDMRP)\, the Department of Defense is announcing the Reconstructive 
 Transplant Research Program (RTRP) for 2019. The Investigator-Initiated Re
 search Award is intended to support studies that have the potential to mak
 e an important contribution to reconstructive transplant research\, patien
 t care\, and/or quality of life. Though the RTRP Investigator-Initiated Re
 search Award mechanism supports groundbreaking research\, all projects mus
 t demonstrate solid scientific rationale with military-relevant utility. M
 ulti-institutional collaborations among clinicians and research scientists
  are encouraged.\n \nTo meet the intent of the FY19 RTRP Investigator-Ini
 tiated Research Award mechanism\, applicants must address at least one of 
 the FY19 RTRP Focus Areas listed at the end of this announcement. Applicat
 ions may focus on any phase of research from basic through translational\,
  including preclinical studies in animal models\, human subjects\, human a
 natomical substances\, as well as correlative studies associated with an e
 xisting clinical trial.\n \nMultiple Principal Investigator (PI) Option: 
 The Investigator-Initiated Research Award mechanism includes an option for
  up to four PIs. One PI will be identified as the Initiating PI and will b
 e responsible for the majority of the administrative tasks associated with
  application submission. The other PI(s) will be identified as a Partnerin
 g PI(s).\n \nFunding:        Maximum USD $ 1’000’000 (Single PI
 )\n                       Maximum USD $ 1’500’00
 0 (Multiple PIs)\n \nDuration:      3 years\n \nEligibility: Applica
 nts from international organizations or institutions are eligible to apply
 \, and there are no citizenship restrictions. Independent investigators at
  all academic levels (or equivalent) are eligible to submit applications.\
 n \nHow to Apply: Pre-applications are submitted through the eBRAP platfo
 rm. They should contain contact information\, a list of collaborators and 
 key personnel\, a preproposal narrative\, and supporting documents as sugg
 ested on the platform. For the Multiple PI option\, the Initiating PI must
  complete the pre-application submission process and submit the contact in
 formation for each Partnering PI. Full applications (by invitation) will b
 e made via a Grants.gov workspace. Full application packages can be downlo
 aded from Grants.gov at any time.\n \nPre-Application Deadline: 17 July 2
 019\, 5:00 p.m. EST (23:00 CET)\nFull Application Deadline:  16 October 2
 019\, 11:59 p.m. EST (05:59 12 Sep\, CET)\n \nGrants.gov Funding Opportun
 ity Number: W81XWH-19-RTRP-IIRA\n \nFurther information\n\n	To see the pr
 ogram announcement\, navigate to the search page on Grants.gov and search 
 for the Opportunity Number W81XWH-19-RTRP-IIRA.\n	For questions about the 
 eBRAP or Grants.gov platforms\, contact the Research Office.\n\n \nFY19 R
 TRP Focus Areas\n \n\n	Reduce the risks of VCA-associated immunosuppressi
 on\n	\n		Define the unique mechanisms of VCA immunogenicity\n		Develop nov
 el approaches for improving VCA immune tolerance\n		Identify unique immuno
 suppression requirements for VCA compared to other solid organ transplants
 \n	\n	\n	Develop reliable non-invasive methods or tools for monitoring VCA
  graft rejection\n	\n		Develop reliable non-invasive biomarkers for monito
 ring chronic VCA graft rejection in a large animal model\n		Identify and/o
 r validate new peripheral biomarkers for acute and chronic rejection\n		De
 velop assays or devices for clinical graft monitoring utilizing validated 
 biomarkers\n	\n	\n	Advance existing or develop innovative ex vivo tissue p
 reservation strategies to extend the timeline between procurement and tran
 splantation\n	\n		Develop novel approaches and models for perfused\, hypot
 hermic\, high subzero and low subzero\, or static preservation strategies\
 n		Determine the extent to which VCA tissue preservation technology impact
 s VCA immunogenicity\n	\n	\n
LOCATION:
STATUS:CONFIRMED
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