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SUMMARY:The Impact of Bone on Whole Organism Physiology
DTSTART:20190906T140000
DTEND:20190906T150000
DTSTAMP:20260919T081923Z
UID:98b43d74c6cd4317d1861ae23507ac382fbcee4441419d1fd1dbd271
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Gerard Karsenty\, Chair\, Genetics & Development Departm
 ent\, University of Columbia\, New York (USA)\nSEMINAR of the LAUSANNE INT
 EGRATIVE METABOLISM and NUTRITION ALLIANCE (LIMNA)\n\nAbstract:\nWe are us
 ing mouse genetics to ask whether we know\, as we assume we do\,  all the
  physiological functions fulfilled by each organ in mammals. This explorat
 ion is based on the belief that physiology\, i.e.\, the science of how org
 ans talk to each other to maintain a whole-organism homeostasis\, has been
  stalled in the last 70 years or so. As a case in study we focus our effor
 ts on the skeleton and are asking does bone have any other function beside
 s making bone? Based on cell biological and clinical observations we have 
 hypothesized that there must be a coordinated control\, endocrine in natur
 e\, of bone growth\, energy metabolism and reproduction. Exploring every t
 enet of this working hypothesis revealed\, as it will be illustrated durin
 g the talk\, that bone is a multipurpose endocrine organ that influences m
 any more physiological processes than simply bone modeling and remodeling.
  Analysis of all the bone-regulated functions reveals a common feature sha
 red by all of them. This in turn suggests that bone may have been invented
  as a survival tool for animals leaving the sea to live on land.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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