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SUMMARY:The emerging concept of down-bound and up-bound modules in the lea
 rning cerebellum
DTSTART:20190719T130000
DTEND:20190719T140000
DTSTAMP:20260916T063200Z
UID:29027974623d2ccb7c631808762cac162293e0d6af2b66fab2477c43
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Chris de Zeeuw\, Dept. of Neuroscience Erasmus MC\, Rott
 erdam.\nThe olivo-cerebellar system is organized into so-called three-elem
 ent modules. These modules are characterized by sagittal zones of Purkinje
  cells that project onto specific parts of the cerebellar and/or vestibula
 r nuclei\, which in turn inhibit the subnucleus of the inferior olive that
  provides the climbing fibers to the connected sagittal zone involved. Yet
 \, despite the generic character of this topographical neuro-anatomical or
 ganization\, recent studies indicate that the modules can be functionally 
 segregated into two main groups\; those with Purkinje cells that fire at a
  relatively low baseline firing frequency of their simple spikes and tend 
 to increase this frequency during learning (referred to as up-bound module
 s)\, and those with Purkinje cells that fire at a relatively high baseline
  frequency and tend to decrease this frequency during learning (referred t
 o as down-bound modules). To date\, this concept has now been shown for le
 arning paradigms like adaptation of the vestibulo-ocular reflex\, modifica
 tion of whisker reflexes\, and eyeblink conditioning. In addition\, eviden
 ce is emerging that these rules can be extrapolated to acquiring cognitive
  functions like decision making and navigation control. In my discussion I
  will highlight that for each of these forms of learning one can predict w
 hether an increase or decrease of simple spike activity is required based 
 on the downstream connectivity.\n\n \nhttps://neuro.nl/\nhttps://nin.nl/r
 esearch/researchgroups/de-zeeuw-groep/\n 
LOCATION:Campus Biotech H8-01-D https://plan.epfl.ch/?room==H8%201%20144.1
 67
STATUS:CONFIRMED
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